N-Demethylerythromycin A

Base Information Edit

Chemical Name:N-Demethylerythromycin A
CAS No.:992-62-1
Molecular Formula:C36H65 N O13
Molecular Weight:719.911
Hs Code.:2941500000
European Community (EC) Number:641-787-6
UNII:5CUO27O3DC
Nikkaji Number:J442.503K
Wikidata:Q27261846
ChEMBL ID:CHEMBL2063468
Mol file:992-62-1.mol

Synonyms:N-Demethylerythromycin A;992-62-1;N-Demethyl Erythromycin A;3'-Demethylerythromyon;N-Desmethyl Erythromycin;Clarithromycin Impurity R;UNII-5CUO27O3DC;Erythromyon, 3'-demethyl-;5CUO27O3DC;(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-6-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;Desmethylerythromycin;Des-N-methylerythromycin;C36H65NO13;N-desmethylerythro-mycin a;Demethylerythromycin A, N-;SCHEMBL9969016;CHEMBL2063468;ERYTHROMYCIN, N-DEMETHYL-;TXOOBKBDBNRQCF-QNPWSHAKSA-N;3''-N-DESMETHYLERYTHROMYCIN A;CS-T-51847;CLARITHROMYCIN IMPURITY R [USP-RS];ERYTHROMYCIN IMPURITY B [EP IMPURITY];Erythromycin Imp. B (EP): N-Demethylerythromycin A;ERYTHROMYCIN ESTOLATE IMPURITY B [EP IMPURITY];Q27261846

Suppliers and Price of N-Demethylerythromycin A

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Demethyl erythromycin A
2mg
$ 426.00

Usbiological
N-Demethyl Erythromycin A
5mg
$ 425.00

TRC
N-DemethylErythromycinA
50mg
$ 1155.00

Sigma-Aldrich
Erythromycin Related Compound N
50mg
$ 1290.00

Sigma-Aldrich
N-Demethylerithromycyn
10mg
$ 1290.00

Cayman Chemical
N-Demethylerythromycin A
10mg
$ 315.00

Cayman Chemical
N-Demethylerythromycin A
5mg
$ 180.00

Cayman Chemical
N-Demethylerythromycin A
1mg
$ 81.00

Cayman Chemical
N-Demethylerythromycin A
500μg
$ 45.00

American Custom Chemicals Corporation
N-DEMETHYL ERYTHROMYCIN A 95.00%
50MG
$ 1732.50

Total 11 raw suppliers

Chemical Property of N-Demethylerythromycin A Edit

Chemical Property:

Vapor Pressure:5.23E-31mmHg at 25°C
Melting Point:142-144掳C
Boiling Point:818.1°Cat760mmHg
PKA:13.09±0.70(Predicted)
Flash Point:448.6°C
PSA：202.70000
Density:1.21g/cm³
LogP:1.83430
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:2.2
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:7
Exact Mass:719.44559113
Heavy Atom Count:50
Complexity:1150

Purity/Quality:

98% ^*data from raw suppliers

N-Demethyl erythromycin A ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)NC)O)(C)O)C)C)O)(C)O
Isomeric SMILES:CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)NC)O)(C)O)C)C)O)(C)O
Uses N-Demethylerythromycin A is a minor co-metabolite of erythromycin produced by Saccharopolyspora erythreae. N-Demethylerythromycin A exhibits a very narrow spectrum of antibiotic activity and is much less active than erythromycins A, B and C. N-Demethyl Erythromycin A (Erythromycin EP Impurity B) is a metabolite of Erythromycin (E649950).

Technology Process of N-Demethylerythromycin A

There total 2 articles about N-Demethylerythromycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%