3,5-dichloro-3H-pyridin-2-one

Base Information

• Chemical Name: 3,5-dichloro-3H-pyridin-2-one
• CAS No.: 5437-33-2
• Deprecated CAS: 13466-37-0
• Molecular Formula: C5H3 Cl2 N O
• Molecular Weight: 163.991
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID3052197
• Mol file: 5437-33-2.mol

Synonyms:3,5-dichloro-3H-pyridin-2-one;DTXSID3052197;MOAVOOCMRUYTSE-UHFFFAOYSA-N

Chemical Property of 3,5-dichloro-3H-pyridin-2-one

Chemical Property:

• Appearance/Colour: white to light beige crystalline powder
• Vapor Pressure: 0.00494mmHg at 25°C
• Melting Point: 180-182 °C(lit.)
• Refractive Index: 1.5680 (estimate)
• Boiling Point: 275.9°Cat760mmHg
• PKA: 8.48±0.10(Predicted)
• Flash Point: 120.7°C
• PSA: 32.86000
• Density: 1.52g/cm³
• LogP: 1.68170
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 162.9591691
• Heavy Atom Count: 9
• Complexity: 197

Purity/Quality:

98% ^*data from raw suppliers

3,5-Dichloro-2-pyridone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T+
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C(C=NC(=O)C1Cl)Cl

Technology Process of 3,5-dichloro-3H-pyridin-2-one

There total 14 articles about 3,5-dichloro-3H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-hydroxy-3,3,5-trichloro-3,4-dihydropyridine (115168-33-7) → 3,5-Dichloro-2-pyridinol (5437-33-2)

Guidance literature:

With triethylamine; In benzene; for 4h; Heating;

DOI:10.1007/BF00473460

Reference yield: 91.0%

2,2,4'-trichloro-5-oxopentanonitrile (98775-57-6) → 3,5-Dichloro-2-pyridinol (5437-33-2)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide; at 110 ℃; for 0.25h;

DOI:10.1007/BF00473460

Reference yield: 86.5%

3,5,6-trichloropyridin-2 ol (6515-38-4) → 3,5-Dichloro-2-pyridinol (5437-33-2)

Guidance literature:

With acetic acid; zinc; In water; at 60 ℃; for 8h; Concentration; Reagent/catalyst; Temperature;

upstream raw materials:

2-Pyridone

3,5-dichloropyridin-2-amine

2-ethoxy-3,5-dichloropyridine

1-fluoro-3,5-dichloropyridinium trifluoromethanesulfonate

Downstream raw materials:

3,5-dichloro-2-bromopyridine

3,5-dichloro-2-(2-nitro-phenoxy)-pyridine

3,5-dichloro-2-pyridinyl tosylate