3-Methoxy-5-(pyridin-2-ylethynyl)pyridine

Base Information

Chemical Name:3-Methoxy-5-(pyridin-2-ylethynyl)pyridine
CAS No.:524924-76-3
Molecular Formula:C13H10N2O
Molecular Weight:210.23100
Hs Code.:
UNII:0868W4SS6C
Nikkaji Number:J1.877.073C
ChEMBL ID:CHEMBL118498
Mol file:524924-76-3.mol

Synonyms:(11C)MPEPy;3-methoxy-5-pyridin-2-ylethynylpyridine

Suppliers and Price of 3-Methoxy-5-(pyridin-2-ylethynyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Methoxy-PEPy >98%
250 mg
$ 1000.00

DC Chemicals
Methoxy-PEPy >98%
100 mg
$ 500.00

Crysdot
Methoxy-PEPy 98+%
100mg
$ 1459.00

Crysdot
Methoxy-PEPy 98+%
50mg
$ 1042.00

Crysdot
Methoxy-PEPy 98+%
10mg
$ 347.00

Crysdot
Methoxy-PEPy 98+%
5mg
$ 243.00

ChemScene
Methoxy-PEPy 98.19%
10mg
$ 150.00

ChemScene
Methoxy-PEPy 98.19%
5mg
$ 90.00

ChemScene
Methoxy-PEPy 98.19%
50mg
$ 450.00

ChemScene
Methoxy-PEPy 98.19%
100mg
$ 750.00

Total 5 raw suppliers

Chemical Property of 3-Methoxy-5-(pyridin-2-ylethynyl)pyridine

Chemical Property:

Boiling Point:395.6±32.0 °C(Predicted)
PKA:2.63±0.10(Predicted)
PSA：35.01000
Density:1.20±0.1 g/cm3(Predicted)
LogP:1.88500
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:210.079312947
Heavy Atom Count:16
Complexity:278

Purity/Quality:

97% ^*data from raw suppliers

Methoxy-PEPy >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CN=CC(=C1)C#CC2=CC=CC=N2

Technology Process of 3-Methoxy-5-(pyridin-2-ylethynyl)pyridine

There total 2 articles about 3-Methoxy-5-(pyridin-2-ylethynyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1945-84-2
2-ethynylpyridine

: 50720-12-2
3-bromo-5-methoxypyridine

: 524924-76-3
3-methoxy-5-(pyridin-2-ylethynyl)pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1016/S0960-894X(02)00997-6

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 524924-76-3
3-methoxy-5-(pyridin-2-ylethynyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / dimethylformamide / 18 h / 60 °C

2: 21 percent / PdCl₂(PPh₃)2; CuI; NEt₃ / dimethylformamide / 3 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1016/S0960-894X(02)00997-6