(2R,3S)-3-(Benzyloxy)-2-hydroxybutanoic acid ethyl ester

Base Information

Chemical Name:(2R,3S)-3-(Benzyloxy)-2-hydroxybutanoic acid ethyl ester
CAS No.:524929-35-9
Molecular Formula:C13H18O4
Molecular Weight:238.284
Hs Code.:
DSSTox Substance ID:DTXSID10448116
Nikkaji Number:J1.889.510B
Wikidata:Q82267060

Synonyms:CTK1E4452;524929-35-9;(2R,3S)-3-(Benzyloxy)-2-hydroxybutanoic acid ethyl ester;DTXSID10448116

Suppliers and Price of (2R,3S)-3-(Benzyloxy)-2-hydroxybutanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-3-(Benzyloxy)-2-hydroxybutanoic acid ethyl ester

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:238.12050905
Heavy Atom Count:17
Complexity:224

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C(C)OCC1=CC=CC=C1)O
Isomeric SMILES:CCOC(=O)[C@@H]([C@H](C)OCC1=CC=CC=C1)O

Technology Process of (2R,3S)-3-(Benzyloxy)-2-hydroxybutanoic acid ethyl ester

There total 1 articles about (2R,3S)-3-(Benzyloxy)-2-hydroxybutanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 118712-09-7
ethyl (2R,3R)-3-methyloxirane-2-carboxilate

: 100-51-6,185532-71-2
benzyl alcohol

: 524929-35-9
ethyl (2R,3S)-3-benzyloxy-2-hydroxybutanoate

Guidance literature:: With magnesium(II) perchlorate; at 50 ℃; for 48h;
DOI:10.1081/SCC-120016307

Reference yield: 82.0%

: 107-30-2
chloromethyl methyl ether

: 524929-35-9
ethyl (2R,3S)-3-benzyloxy-2-hydroxybutanoate

: 524929-43-9
(2R,3S)-3-Benzyloxy-2-methoxymethoxy-butyric acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 12h;
DOI:10.1055/s-2003-36777

Reference yield:

: 524929-35-9
ethyl (2R,3S)-3-benzyloxy-2-hydroxybutanoate

: 524929-37-1
(2R,3S)-3-Benzyloxy-2-methoxymethoxy-butyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / i-Pr₂EtN / 12 h / 20 °C

2: 82 percent / DIBAL-H / toluene / 12 h / -30 - 20 °C

3: 90 percent / (COCl)2; DMSO; Et₃N

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In toluene; 3: Swern oxidation;
DOI:10.1055/s-2003-36777