methyl 4-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl ether

Base Information

• Chemical Name: methyl 4-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl ether
• CAS No.: 52596-94-8
• Molecular Formula: C16H14N2O2
• Molecular Weight: 266.299
• Mol file: 52596-94-8.mol

Synonyms:2-(4-methoxyphenyl)-5-p-tolyl-1,3,4-oxadiazole;2-p-Tolyl-5-<4-methoxy-phenyl>-1,3,4-oxdiazol;2-(p-Tolyl)-5-(4-methoxy-phenyl)-1,3,4-oxadiazol;2-(4-Methoxy-phenyl)-5-p-tolyl-[1,3,4]oxadiazole;2-(p-methoxyphenyl)-5-(p-tolyl)-1,3,4-oxadiazole;2-(4-methoxyphenyl)-5-(4-methylphenyl)-1,3,4-oxadiazole;

Chemical Property of methyl 4-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl ether

Chemical Property:

• Melting Point: 137 - 138 °C
• PSA: 48.15000
• LogP: 3.72060

Purity/Quality:

99% ^*data from raw suppliers

2-(4-methoxyphenyl)-5-(4-methylphenyl)-1,3,4-oxadiazole ^*data from reagent suppliers

Safty Information:

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Technology Process of methyl 4-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl ether

There total 17 articles about methyl 4-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-methyl-benzaldehyde (104-87-0) + 4-methoxybenzoic acid hydrazide (3290-99-1) → 2-(4-methoxyphenyl)-5-(p-tolyl)-1,3,4-oxadiazole (52596-94-8)

Guidance literature:

With trichloroisocyanuric acid; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1080/00397910802054289

Reference yield: 84.0%

4-Methoxy-benzoic acid [1-p-tolyl-meth-(E)-ylidene]-hydrazide (115540-64-2) → 2-(4-methoxyphenyl)-5-(p-tolyl)-1,3,4-oxadiazole (52596-94-8)

Guidance literature:

4-Methoxy-benzoic acid [1-p-tolyl-meth-(E)-ylidene]-hydrazide; With iodine; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; Green chemistry;

With dihydrogen peroxide; In water; dimethyl sulfoxide; at 20 ℃; for 4h; Green chemistry;

DOI:10.1039/c3ra44897e

Reference yield: 80.0%

1-(4-methoxybenzoyl)-2-(4-methylbenzylidene)hydrazine → 2-(4-methoxyphenyl)-5-(p-tolyl)-1,3,4-oxadiazole (52596-94-8)

Guidance literature:

With trichloroisocyanuric acid; In ethanol; at 20 ℃; for 0.25h;

DOI:10.1080/00397910802054289

upstream raw materials:

4-methoxybenzoic acid hydrazide

4-methyl-benzoyl chloride

4-Methoxy-benzoic acid [1-p-tolyl-meth-(E)-ylidene]-hydrazide

4-methyl-benzaldehyde

Downstream raw materials:

2-(4-methoxy-phenyl)-5-{4-[2-(5-methyl-2-phenyl-2H-[1,2,3]triazol-4-yl)-vinyl]-phenyl}-[1,3,4]oxadiazole

2-{4-[4-(5-chloro-2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-5-(4-methoxy-phenyl)-[1,3,4]oxadiazole

2-{4-[4-(2,5-diphenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-5-(4-methoxy-phenyl)-[1,3,4]oxadiazole

2-{4-[4-(4-chloro-5-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-5-(4-methoxy-phenyl)-[1,3,4]oxadiazole

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