Carbonic acid, [3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,3, 4-benzotriazepin-3-yl]acetyl]amino]phenyl]methyl methyl ester

Base Information

Chemical Name:Carbonic acid, [3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,3, 4-benzotriazepin-3-yl]acetyl]amino]phenyl]methyl methyl ester
CAS No.:528883-05-8
Molecular Formula:C31H38N4O6
Molecular Weight:562.666
Hs Code.:

Carbonic acid,
[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,3,
4-benzotriazepin-3-yl]acetyl]amino]phenyl]methyl methyl ester

Synonyms:

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Chemical Property of Carbonic acid, [3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,3, 4-benzotriazepin-3-yl]acetyl]amino]phenyl]methyl methyl ester

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Technology Process of Carbonic acid, [3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,3, 4-benzotriazepin-3-yl]acetyl]amino]phenyl]methyl methyl ester

There total 8 articles about Carbonic acid, [3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,3, 4-benzotriazepin-3-yl]acetyl]amino]phenyl]methyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 269071-78-5
3-aminobenzyl methyl carbonate

: 528882-12-4
(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid

: 528883-05-8
(3-(2-(5-cyclohexyl-1,2-dihydro-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetamido)phenyl)methyl methyl carbonate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm051219x

Reference yield:

: 885514-89-6
3-nitrobenzyl methyl carbonate

: 528883-05-8
(3-(2-(5-cyclohexyl-1,2-dihydro-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetamido)phenyl)methyl methyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / SnCl₂*H₂O / ethyl acetate / 1 h / Heating

2: 96 percent / 1-hydroxybenzotriazole; 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm051219x

Reference yield:

: (N'-((2-amino-phenyl)cyclohexyl-methylene)hydrazino)acetic acid ethyl ester

: 528883-05-8
(3-(2-(5-cyclohexyl-1,2-dihydro-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetamido)phenyl)methyl methyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / NEt₃ / CH₂Cl₂ / 1 h / 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 84 percent / dimethylformamide / 2 h / 20 °C

3.1: 95 percent / aq. NaOH / ethanol / 16 h / 20 °C

4.1: 96 percent / 1-hydroxybenzotriazole; 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With dmap; sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm051219x