4-Oxazolecarboxylic acid, 2-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Base Information

Chemical Name:4-Oxazolecarboxylic acid, 2-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-
CAS No.:528885-22-5
Molecular Formula:C32H35N5O6
Molecular Weight:585.66
Hs Code.:

4-Oxazolecarboxylic acid,
2-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1,
3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Synonyms:

Suppliers and Price of 4-Oxazolecarboxylic acid, 2-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Oxazolecarboxylic acid, 2-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Oxazolecarboxylic acid, 2-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]-

There total 12 articles about 4-Oxazolecarboxylic acid, 2-[3-[[[5-cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-1,2-dihydro-2-oxo-3H-1, 3,4-benzotriazepin-3-yl]acetyl]amino]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 528885-13-4
2-(3-{2-[5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl]-acetylamino}-phenyl)-oxazole-4-carboxylic acid methyl ester

: 528885-22-5
2-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-oxazole-4-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jm070139l

Reference yield:

: methyl 2-(3-nitrobenzamido)-3-hydroxypropanoate

: 528885-22-5
2-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 21 percent / PPh₃; DBU / acetonitrile; CCl₄ / 1.33 h / 0 - 20 °C

2: 100 percent / H₂ / Pd/C / dioxane

3: 72 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

4: 96 percent / aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With dmap; lithium hydroxide; hydrogen; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm070139l

Reference yield:

: 942232-57-7
2-(3-nitro-phenyl)-oxazole-4-carboxylic acid methyl ester

: 528885-22-5
2-(3-(2-(5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-phenyl)-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / dioxane

2: 72 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

3: 96 percent / aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With dmap; lithium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l