3-(3-PHENOXYPHENYL)PROPIONIC ACID

Base Information

• Chemical Name: 3-(3-PHENOXYPHENYL)PROPIONIC ACID
• CAS No.: 52888-70-7
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Hs Code.: 2918990090
• Mol file: 52888-70-7.mol

Synonyms:3-(3-bromopropyl)diphenyl ether;3-(3-phenoxyphenyl)propanoic acid;1-bromo-3-(3-phenoxyphenyl)propane;3-(3-phenoxyphenyl)-1-bromopropane;Benzene,1-(3-bromopropyl)-3-phenoxy;3-(3-phenoxyphenyl)propyl bromide;

Chemical Property of 3-(3-PHENOXYPHENYL)PROPIONIC ACID

Chemical Property:

• Melting Point: 62～64℃
• PSA: 46.53000
• LogP: 3.49610

Purity/Quality:

98%min ^*data from raw suppliers

3-(3-Phenoxyphenyl)propionic acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-PHENOXYPHENYL)PROPIONIC ACID

There total 8 articles about 3-(3-PHENOXYPHENYL)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

→ 3-(3-phenoxyphenyl)propionic acid (52888-70-7)

Guidance literature:

With 4-t-butylbenzenethiol; sodium t-butanolate; In 1-methyl-pyrrolidin-2-one; tert-butyl alcohol; at 25 ℃; for 24h; under 760.051 Torr; Schlenk technique; Sealed tube; Irradiation;

Reference yield:

(E)-3-(3-phenoxyphenyl)acrylic acid (77124-20-0) → 3-(3-phenoxyphenyl)propionic acid (52888-70-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 16h; under 4121.6 Torr;

Reference yield:

ethyl 3-(3-phenoxyphenyl)propanoate (52888-69-4) → 3-(3-phenoxyphenyl)propionic acid (52888-70-7)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 3h; Reflux;

DOI:10.1016/j.bmcl.2011.12.022

upstream raw materials:

2-(3-Phenoxy-benzyl)-malonic acid

3-phenoxybenzyl bromide

2-(3-Phenoxy-benzyl)-malonic acid diethyl ester

(E)-3-(3-phenoxyphenyl)acrylic acid

Downstream raw materials:

N-(3-chlorophenyl)-3-(3-phenoxyphenyl)propanamide

Refernces

• 1、 Yang, Yinghong,Wang, Zhenling,Yang, Jianzhong,Yang, Tao,Pi, Weiyi,Ang, Wei,Lin, Yanni,Liu, Yuanyuan,Li, Zicheng,Luo, Youfu,Wei, Yuquan. "Design, synthesis and evaluation of novel molecules with a diphenyl ether nucleus as potential antitubercular agents". . p. 954 - 957. Retrieved 2012/03/11.
• 2、 Adams, Jerry L.,Garigipati, Ravi S.,Sorenson, Margaret,Schmidt, Stanley J.,Brian, William R.,Newton, John F.,Tyrrell, Kathy A.,Garver, Eric,Yodis, Lee A.,Chabot-Fletcher, Marie,Tzimas, Maritsa,Webb, Edward F.,Breton, John J.,Griswold, Don E.. "Bicyclic N-hydroxyurea inhibitors of 5-lipoxygenase: Pharmacodynamic, pharmacokinetic, and in vitro metabolic studies characterizing N-hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea". . p. 5035 - 5046. Retrieved 2007/10/03.