6-methylangelicin

Base Information

• Chemical Name: 6-methylangelicin
• CAS No.: 90370-14-2
• Molecular Formula: C₁₂H₈O₃
• Molecular Weight: 200.194
• Mol file: 90370-14-2.mol

Synonyms:6-Methylangelicin

Chemical Property of 6-methylangelicin

Chemical Property:

• Vapor Pressure: 9.97E-06mmHg at 25°C
• Melting Point: 164 - 165 °C (methanol)
• Boiling Point: 371.9°Cat760mmHg
• Flash Point: 178.7°C
• PSA: 43.35000
• Density: 1.332g/cm³
• LogP: 2.84760

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methylangelicin

There total 4 articles about 6-methylangelicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-hydroxy-6-methylcoumarin (53811-56-6) → 6-methylangelicin (90370-14-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / K₂CO₃ / acetone / 5 h / Heating

2: 55.3 percent / N,N-diethylaniline / 2 h / Heating

3: 1.) O₃, 2.) H₂ / 2.) 10percent Pd/CaCO₃ / 1.) EtOAc, 2.) EtOAc

4: 85percent aq. H₃PO₄ / 0.5 h / 100 °C

With phosphoric acid; hydrogen; potassium carbonate; ozone; N,N-diethylaniline; Lindlar's catalyst; In acetone;

DOI:10.1021/jm00374a005

Reference yield:

(7-Hydroxy-6-methyl-2-oxo-2H-chromen-8-yl)-acetaldehyde (91271-97-5) → 6-methylangelicin (90370-14-2)

Guidance literature:

With phosphoric acid; at 100 ℃; for 0.5h; Yield given;

DOI:10.1021/jm00374a005

Reference yield:

6-methyl-7-(allyloxy)coumarin (90369-99-6) → 6-methylangelicin (90370-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 55.3 percent / N,N-diethylaniline / 2 h / Heating

2: 1.) O₃, 2.) H₂ / 2.) 10percent Pd/CaCO₃ / 1.) EtOAc, 2.) EtOAc

3: 85percent aq. H₃PO₄ / 0.5 h / 100 °C

With phosphoric acid; hydrogen; ozone; N,N-diethylaniline; Lindlar's catalyst;

DOI:10.1021/jm00374a005

upstream raw materials:

(7-Hydroxy-6-methyl-2-oxo-2H-chromen-8-yl)-acetaldehyde

7-hydroxy-6-methylcoumarin

6-methyl-7-(allyloxy)coumarin

6-methyl-7-hydroxy-8-allylcoumarin

Refernces