Technology Process of cytarazid
There total 11 articles about cytarazid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 ℃;
for 0.75h;
DOI:10.1021/jm00107a018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: phosphoryl oxychloride, triethylamine / acetonitrile
2: NH4OH
3: 80 percent / tetrabutylammonium fluoride
With
ammonium hydroxide; tetrabutyl ammonium fluoride; phosphoryl oxychloride on N,N-dimethylformamide; triethylamine;
In
acetonitrile;
DOI:10.1248/cpb.37.1659
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / diethyl azodicarboxylate, triphenyl phosphorazidate, triphenylphosphine / tetrahydrofuran / 4 h / Ambient temperature
2: 94 percent / concd. NH4OH / methanol / 1.5 h / Ambient temperature
3: tetrabutylammonium bromide, 0.2 M aq. NaHCO3 / CH2Cl2 / 6.5 h / Ambient temperature
4: concd. NH4OH / dioxane / Ambient temperature
5: 100 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 0.75 h / 0 °C
With
ammonium hydroxide; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm00107a018
