7-BROMO-9-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE

Base Information

• Chemical Name: 7-BROMO-9-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE
• CAS No.: 53618-67-0
• Molecular Formula: C13H11BrClN
• Molecular Weight: 296.59000
• Mol file: 53618-67-0.mol

Synonyms:7-Brom-9-chlor-1,2,3,4-tetrahydro-acridin;Acridine,7-bromo-9-chloro-1,2,3,4-tetrahydro;7-bromo-9-chloro-1,2,3,4-tetrahydro-acridine;6-Brom-4-chlor-2,3-tetramethylenchinolin;

Chemical Property of 7-BROMO-9-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE

Chemical Property:

• PSA: 12.89000
• LogP: 4.52950

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BROMO-9-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE

There total 6 articles about 7-BROMO-9-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 5-Bromo-2-aminobenzoic acid (5794-88-7) → 6-Brom-4-chlor-2,3-tetramethylenchinolin (53618-67-0)

Guidance literature:

With trichlorophosphate; In neat (no solvent); at 115 ℃;

DOI:10.1021/acs.jmedchem.1c00160

Reference yield:

5-bromo-2-aminobenzoic acid methyl ester (52727-57-8) → 6-Brom-4-chlor-2,3-tetramethylenchinolin (53618-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 20 °C

2: trichlorophosphate / neat (no solvent) / 115 °C

With sodium hydroxide; trichlorophosphate; In water;

DOI:10.1021/acs.jmedchem.1c00160

Reference yield:

7-bromo-1,2,3,4-tetrahydro-acridin-9-ol (443662-39-3,909207-92-7) → 6-Brom-4-chlor-2,3-tetramethylenchinolin (53618-67-0)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1039/jr9390000784

upstream raw materials:

7-bromo-1,2,3,4-tetrahydro-acridin-9-ol

4-hydroxy-2,3-(tetramethylene)quinoline

cyclohexanone

5-Bromo-2-aminobenzoic acid