(4-METHOXYPHENYL)[6-(4-METHOXYPHENYL)-3-PYRIDINYL]METHANONE

Base Information

• Chemical Name: (4-METHOXYPHENYL)[6-(4-METHOXYPHENYL)-3-PYRIDINYL]METHANONE
• CAS No.: 53670-04-5
• Molecular Formula: C20H17NO3
• Molecular Weight: 319.36
• Mol file: 53670-04-5.mol

Synonyms:

Chemical Property of (4-METHOXYPHENYL)[6-(4-METHOXYPHENYL)-3-PYRIDINYL]METHANONE

Chemical Property:

• PSA: 48.42000
• LogP: 3.99680

Purity/Quality:

95%-98% ^*data from raw suppliers

(4-Methoxyphenyl)[6-(4-methoxyphenyl)-3-pyridinyl]methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-METHOXYPHENYL)[6-(4-METHOXYPHENYL)-3-PYRIDINYL]METHANONE

There total 2 articles about (4-METHOXYPHENYL)[6-(4-METHOXYPHENYL)-3-PYRIDINYL]METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-dimethylamino-4'-methoxyacrylophenone (18096-70-3,78090-00-3) → (4-methoxyphenyl)-[6-(4-methoxyphenyl)pyridin-3-yl]methanone (53670-04-5)

Guidance literature:

With ammonium acetate; In acetic acid; for 1h; Heating;

DOI:10.1002/jhet.5570390528

Reference yield:

→ (4-methoxyphenyl)-[6-(4-methoxyphenyl)pyridin-3-yl]methanone (53670-04-5)

Guidance literature:

Hydroxymethylen-p-phenyl-acetophenon (1c);

DOI:10.1007/BF00907383

Reference yield:

(4-methoxyphenyl)-[6-(4-methoxyphenyl)pyridin-3-yl]methanone (53670-04-5) → 5-(4-methoxybenzoyl)-2-(4-methoxyphenyl)piperidin-1-ium chloride + 5-(4-methoxybenzoyl)-2-(4-methoxyphenyl)piperidin-1-ium chloride

Guidance literature:

(4-methoxyphenyl)-[6-(4-methoxyphenyl)pyridin-3-yl]methanone; With N,N,N,N,N,N-hexamethylphosphoric triamide; In dichloromethane; at 25 ℃; for 0.166667h; Inert atmosphere;

With trichlorosilane; In dichloromethane; at 25 ℃; for 24h; Overall yield = 45 %; Inert atmosphere;

DOI:10.3390/molecules24030401

upstream raw materials:

3-dimethylamino-4'-methoxyacrylophenone

Refernces