N-[N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl]-D-glutamic acid 5-(phenylmethyl) ester

Base Information

• Chemical Name: N-[N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl]-D-glutamic acid 5-(phenylmethyl) ester
• CAS No.: 53759-36-7
• Molecular Formula: C20H28N2O7
• Molecular Weight: 408.452
• Mol file: 53759-36-7.mol

Synonyms:Boc-ADE(Bzl)-OH;t-butyloxycarbonyl-L-alanyl-D-glutamic α-benzyl ester;γ-benzyl tert-butoxycarbonyl-L-alanyl-D-glutamate;N-tert-butyloxycarbonyl-L-alanyl-D-glutamic acid γ-benzyl ester;

Chemical Property of N-[N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl]-D-glutamic acid 5-(phenylmethyl) ester

Chemical Property:

• PSA: 131.03000
• LogP: 2.77440
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-5-(Benzyloxy)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-5-oxopentanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl]-D-glutamic acid 5-(phenylmethyl) ester

There total 5 articles about N-[N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl]-D-glutamic acid 5-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

D-glutamic acid-5-benzyl ester (2578-33-8,1676-73-9,29456-09-5,25014-27-1) + Boc-Ala-O-N-hydroxysuccinimide (3392-05-0) → γ-benzyl tert-butoxycarbonyl-L-alanyl-D-glutamate (53759-36-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 24.5h; Inert atmosphere;

DOI:10.3390/molecules26216352

Reference yield: 87.8%

→ γ-benzyl tert-butoxycarbonyl-L-alanyl-D-glutamate (53759-36-7)

Guidance literature:

Reference yield:

D-Glutamic acid (6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → γ-benzyl tert-butoxycarbonyl-L-alanyl-D-glutamate (53759-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 21 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 24.5 h / 0 °C / Inert atmosphere

With boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran;

DOI:10.3390/molecules26216352

upstream raw materials:

D-glutamic acid-5-benzyl ester

Boc-Ala-O-N-hydroxysuccinimide

L-N-Boc-Ala

D-Glutamic acid

Downstream raw materials:

α-octadecylamide of γ-benzyl tert-butoxycarbonyl-L-alanyl-D-glutamate

Boc-Ala-^DGlu(Bzl)-Phe-CONHCH₂COCH₃

Boc-Ala-^DGlu(OBzl)-Phe-CO₂CH₂COCH₃

C₂₁H₃₀N₂O₇

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 53759-36-7 N-[N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl]-D-glutamic acid 5-(phenylmethyl) ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send