1-Propanone, 1-[(2R,6S)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]acetyl]tetrahydro-2H- pyran-2-yl]-3-[(4R,5R)-5-dodecyl-2,2-dimethyl-1,3-dioxolan-4-yl]-

Base Information

Chemical Name:1-Propanone, 1-[(2R,6S)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]acetyl]tetrahydro-2H- pyran-2-yl]-3-[(4R,5R)-5-dodecyl-2,2-dimethyl-1,3-dioxolan-4-yl]-
CAS No.:537665-81-9
Molecular Formula:C₄₃H₆₆O₆Si
Molecular Weight:707.079
Hs Code.:

1-Propanone,
1-[(2R,6S)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]acetyl]tetrahydro-2H-
pyran-2-yl]-3-[(4R,5R)-5-dodecyl-2,2-dimethyl-1,3-dioxolan-4-yl]-

Synonyms:

Suppliers and Price of 1-Propanone, 1-[(2R,6S)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]acetyl]tetrahydro-2H- pyran-2-yl]-3-[(4R,5R)-5-dodecyl-2,2-dimethyl-1,3-dioxolan-4-yl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Propanone, 1-[(2R,6S)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]acetyl]tetrahydro-2H- pyran-2-yl]-3-[(4R,5R)-5-dodecyl-2,2-dimethyl-1,3-dioxolan-4-yl]-

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Technology Process of 1-Propanone, 1-[(2R,6S)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]acetyl]tetrahydro-2H- pyran-2-yl]-3-[(4R,5R)-5-dodecyl-2,2-dimethyl-1,3-dioxolan-4-yl]-

There total 6 articles about 1-Propanone, 1-[(2R,6S)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]acetyl]tetrahydro-2H- pyran-2-yl]-3-[(4R,5R)-5-dodecyl-2,2-dimethyl-1,3-dioxolan-4-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 537665-73-9
(2R,3S,7R,8R,11R,12R)-1-t-butyldiphenylsilyloxy-11,12-(isopropylidenedioxy)-3,7-oxido-2,8-tetracosanediol

: 537665-81-9
(3S,7R,11R,12R)-1-t-butyldiphenylsilyloxy-11,12-(isopropylidenedioxy)-3,7-oxido-2,8-tetracosanedione

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1016/S0040-4020(03)00135-2

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 537665-81-9
(3S,7R,11R,12R)-1-t-butyldiphenylsilyloxy-11,12-(isopropylidenedioxy)-3,7-oxido-2,8-tetracosanedione

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / imidazole / dimethylformamide; CH₂Cl₂ / 12 h / 0 - 20 °C

2: AD-mix β; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 14 h / 0 °C

3: d-camphorsulfonic acid / CH₂Cl₂ / 2 h / 20 °C

4: 226 mg / d-camphorsulfonic acid / CH₂Cl₂ / 3.5 h / 20 °C

5: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 6 h / 20 °C

With 1H-imidazole; methanesulfonamide; (1S)-10-camphorsulfonic acid; sodium hydrogencarbonate; Dess-Martin periodane; 1,4-bis(9-O-dihydroquinidine)phthalazine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4020(03)00135-2

Reference yield:

: 485322-59-6
(2R,3R,7R,8R,11R,12R)-1-t-butyldiphenylsilyloxy-2,3-oxido-7,8,11,12-tetracosanetetraol

: 537665-81-9
(3S,7R,11R,12R)-1-t-butyldiphenylsilyloxy-11,12-(isopropylidenedioxy)-3,7-oxido-2,8-tetracosanedione

Guidance literature:: Multi-step reaction with 3 steps

1: d-camphorsulfonic acid / CH₂Cl₂ / 2 h / 20 °C

2: 226 mg / d-camphorsulfonic acid / CH₂Cl₂ / 3.5 h / 20 °C

3: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 6 h / 20 °C

With (1S)-10-camphorsulfonic acid; sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane;
DOI:10.1016/S0040-4020(03)00135-2