2-Ethyl-6-methoxyaniline

Base Information

• Chemical Name: 2-Ethyl-6-methoxyaniline
• CAS No.: 53982-01-7
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• European Community (EC) Number: 845-773-2
• DSSTox Substance ID: DTXSID30435225
• Wikidata: Q82250006
• Mol file: 53982-01-7.mol

Synonyms:2-Ethyl-6-methoxyaniline;53982-01-7;Benzenamine, 2-ethyl-6-methoxy-;2-ethyl-6-methoxybenzenamine;SCHEMBL5829892;DTXSID30435225;UWFPKMKMBZCSSP-UHFFFAOYSA-N;AKOS024049751;SB76502;EN300-190945

Chemical Property of 2-Ethyl-6-methoxyaniline

Chemical Property:

• PSA: 35.25000
• LogP: 2.42100
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

2-Ethyl-6-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(C(=CC=C1)OC)N

Technology Process of 2-Ethyl-6-methoxyaniline

There total 13 articles about 2-Ethyl-6-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl 2-ethyl-6-methoxyphenylcarbamate (398136-31-7) + trimethylsilyl iodide (16029-98-4) → 2-Ethyl-6-methoxyaniline (53982-01-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1021/ol016966c

Reference yield: 43.0%

2-Nitro-3-(1-hydroxyethyl)anisole (195529-68-1) → 2-Ethyl-6-methoxyaniline (53982-01-7)

Guidance literature:

With phosphoric acid; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/jm990170q

Reference yield:

tert-butyl 2-ethyl-6-methoxyphenylcarbamate (398136-31-7) → 2-Ethyl-6-methoxyaniline (53982-01-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h;

upstream raw materials:

2-Methoxy-6-vinyl-1-nitrobenzene

2-Nitro-3-(1-hydroxyethyl)anisole

tert-butyl 2-ethyl-6-methoxyphenylcarbamate

trimethylsilyl iodide

Downstream raw materials:

2-amino-3-ethylphenol

1-(2-Ethyl-6-methoxy-phenyl)-3-pentyl-urea

1-(2-Ethyl-6-hydroxy-phenyl)-3-pentyl-urea

2-Chloro-N-(2-ethyl-6-methoxy-phenyl)-N-(2-methoxy-1-methyl-ethyl)-acetamide