1H-Indole-1-carboxylic acid, 3-[(2R)-3-oxo-3-[(2-phenylethyl)amino]-2-[[[4-(phenylmethyl)-1-piperidin yl]acetyl]amino]propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 3-[(2R)-3-oxo-3-[(2-phenylethyl)amino]-2-[[[4-(phenylmethyl)-1-piperidin yl]acetyl]amino]propyl]-, 1,1-dimethylethyl ester
CAS No.:540483-73-6
Molecular Formula:C38H46N4O4
Molecular Weight:622.808
Hs Code.:

1H-Indole-1-carboxylic acid,
3-[(2R)-3-oxo-3-[(2-phenylethyl)amino]-2-[[[4-(phenylmethyl)-1-piperidin
yl]acetyl]amino]propyl]-, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of 1H-Indole-1-carboxylic acid, 3-[(2R)-3-oxo-3-[(2-phenylethyl)amino]-2-[[[4-(phenylmethyl)-1-piperidin yl]acetyl]amino]propyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-Indole-1-carboxylic acid, 3-[(2R)-3-oxo-3-[(2-phenylethyl)amino]-2-[[[4-(phenylmethyl)-1-piperidin yl]acetyl]amino]propyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-Indole-1-carboxylic acid, 3-[(2R)-3-oxo-3-[(2-phenylethyl)amino]-2-[[[4-(phenylmethyl)-1-piperidin yl]acetyl]amino]propyl]-, 1,1-dimethylethyl ester

There total 6 articles about 1H-Indole-1-carboxylic acid, 3-[(2R)-3-oxo-3-[(2-phenylethyl)amino]-2-[[[4-(phenylmethyl)-1-piperidin yl]acetyl]amino]propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 438634-64-1
(4-benzylpiperidin-1-yl)-acetic acid

: 540483-63-4
tert-butyl-3-{(2R)-2-amino-2-[1-(2-phenylethyl)carbamoyl]ethyl}-1H-1-indolecarboxylate

: 540483-73-6
N₁-(2-phenylethyl)-(2R)-2-{[(4-benzylpiperidino)methyl]carboxamido}-3-[1-(tert-butoxycarbonyl)-3-indolyl]propanamide

Guidance literature:: With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0210921

Reference yield:

: 31252-42-3
4-benzylpyperidine

: 540483-73-6
N₁-(2-phenylethyl)-(2R)-2-{[(4-benzylpiperidino)methyl]carboxamido}-3-[1-(tert-butoxycarbonyl)-3-indolyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / toluene / 20 °C

2: 100 percent / aq. NaOH / methanol / 20 °C

3: 79 percent / HOBt; TBTU; DIEA / dimethylformamide / 20 °C

With sodium hydroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0210921

Reference yield:

: 64-04-0
phenethylamine

: 540483-73-6
N₁-(2-phenylethyl)-(2R)-2-{[(4-benzylpiperidino)methyl]carboxamido}-3-[1-(tert-butoxycarbonyl)-3-indolyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / HOBt; TBTU; DIEA / dimethylformamide / 1 h

2: 97 percent / piperidine / dimethylformamide / 0.5 h / 20 °C

3: 79 percent / HOBt; TBTU; DIEA / dimethylformamide / 20 °C

With piperidine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm0210921