Chemical Property of Ampiroxicam
Chemical Property:
- Appearance/Colour:Powder
- Melting Point:159-161?C
- Refractive Index:1.629
- PKA:12.74±0.20(Predicted)
- PSA：132.51000
- Density:1.44 g/cm3
- LogP:3.65040
- Storage Temp.:-20°C Freezer
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- XLogP3:4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:8
- Exact Mass:447.11002119
- Heavy Atom Count:31
- Complexity:808
- Purity/Quality:
-
99%, *data from raw suppliers
Ampiroxicam *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCOC(=O)OC(C)OC1=C(N(S(=O)(=O)C2=CC=CC=C21)C)C(=O)NC3=CC=CC=N3
- Recent ClinicalTrials:Fludarabine (Fludara?) Plus Alemtuzumab (CAMPATH?, MabCampath?) vs Fludarabine Alone in B-Cell Chronic Lymphocytic Leukemia (B-CLL) Patients
-
Description
Ampiroxicam is a once-daily non-steroidal anti-inflammatory drug (NSAID)
introduced in Japan. As a non-acidic ether carbonate prodrug of the widely used
antiinflammatory agent, piroxicam, ampiroxicam is similar or more potent than
piroxicam in suppressing carrageenan edema, ultraviolet erythema, traumatic edema,
capillary permeability, acetic acid writhing, yeast algesia and yeast hyperthermia in
many animals. Eioavailability studies in man show undetectable plasma levels of
ampiroxicam indicating 100% conversion to piroxicam during absorption process.
Ampiroxicam has been reported to have fewer side effects on the gastric mucosa
than piroxicam.
-
Uses
Prodrug of Piroxicam. Anti-inflammatory.
