Technology Process of 2-Cyclopentene-1,1-dicarboxylic acid, diethyl ester
There total 2 articles about 2-Cyclopentene-1,1-dicarboxylic acid, diethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; formic acid; sodium hydride;
at 40 ℃;
for 6h;
Temperature;
Inert atmosphere;
DOI:10.1039/c4ob02480j
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 1 h / 40 °C / Inert atmosphere
2: sodium hydride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; formic acid / 6 h / 40 °C / Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; formic acid; sodium hydride;
In
dichloromethane;
DOI:10.1039/c4ob02480j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 4.93 g / aq. NaOH / ethanol / 15 h / 20 °C
2: Et3N / acetone / 0.5 h / 20 °C
3: aq. NaN3 / acetone / 1 h / 0 °C
4: benzene / 3 h / Heating
5: 2.05 g / aq. HCl / tetrahydrofuran
With
hydrogenchloride; sodium hydroxide; sodium azide; triethylamine;
In
tetrahydrofuran; ethanol; acetone; benzene;
4: Curtius rearrangement;
DOI:10.1016/S0014-827X(03)00107-1
