O-Desmethylcarvedilol

Base Information

Chemical Name:O-Desmethylcarvedilol
CAS No.:72956-44-6
Molecular Formula:C23H24 N2 O4
Molecular Weight:392.4477
Hs Code.:
UNII:W0HIU4LI95
DSSTox Substance ID:DTXSID60993727
Nikkaji Number:J460.694I
Wikidata:Q27292144
Metabolomics Workbench ID:42542
ChEMBL ID:CHEMBL2440861
Mol file:72956-44-6.mol

Synonyms:demethylcarvedilol;desmethylcarvedilol

Suppliers and Price of O-Desmethylcarvedilol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
O-Desmethylcarvedilol
5mg
$ 460.00

TRC
O-DesmethylCarvedilol
50mg
$ 1455.00

Medical Isotopes, Inc.
O-DesmethylCarvedilol
5 mg
$ 870.00

Biosynth Carbosynth
O-Desmethyl carvedilol
25 mg
$ 721.00

Biosynth Carbosynth
O-Desmethyl carvedilol
10 mg
$ 396.50

Biosynth Carbosynth
O-Desmethyl carvedilol
50 mg
$ 1310.50

Biosynth Carbosynth
O-Desmethyl carvedilol
2 mg
$ 120.00

American Custom Chemicals Corporation
ORTHO-DESMETHYL CARVEDILOL 95.00%
50MG
$ 1686.30

American Custom Chemicals Corporation
ORTHO-DESMETHYL CARVEDILOL 95.00%
5MG
$ 345.40

Total 11 raw suppliers

Chemical Property of O-Desmethylcarvedilol

Chemical Property:

Vapor Pressure:2.39E-19mmHg at 25°C
Melting Point:158-160°C
Boiling Point:678.7 °C at 760 mmHg
PKA:9?+-.0.30(Predicted)
Flash Point:364.3 °C
PSA：86.74000
Density:1.31 g/cm³
LogP:3.82590
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated), THF (Slightly)
XLogP3:3.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:392.17360725
Heavy Atom Count:29
Complexity:494

Purity/Quality:

95% ^*data from raw suppliers

O-Desmethylcarvedilol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C3=C(N2)C=CC=C3OCC(CNCCOC4=CC=CC=C4O)O
Uses A metabolite of the nonselective -adrenergic blocker with a1-blocking activity. A metabolite of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity.

Technology Process of O-Desmethylcarvedilol

There total 6 articles about O-Desmethylcarvedilol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1479049-26-7
5-[(9H-carbazol-4-yloxy)methyl]-3-[2-(2-hydroxyphenoxy)ethyl]-2-oxazolidinone

: 72956-44-6,123372-13-4,123372-14-5
Desmethylcarvedilol

Guidance literature:: With sodium hydroxide; In ethanol; Reflux;
DOI:10.1021/jm401090a

Reference yield:

: 180987-80-8
5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one

: 72956-44-6,123372-13-4,123372-14-5
Desmethylcarvedilol

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 20 °C

2: sodium hydroxide / ethanol / Reflux

With boron tribromide; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1021/jm401090a

Reference yield:

: 51997-51-4,95093-96-2
4-(2,3-epoxypropoxy)carbazole

: 72956-44-6,123372-13-4,123372-14-5
Desmethylcarvedilol

Guidance literature:: Multi-step reaction with 4 steps

1: isopropyl alcohol / 2 h / Reflux

2: triethylamine / dichloromethane / 5 h / 20 °C

3: boron tribromide / dichloromethane / 20 °C

4: sodium hydroxide / ethanol / Reflux

With boron tribromide; triethylamine; sodium hydroxide; In ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm401090a