4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-

Base Information

Chemical Name:4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-
CAS No.:544681-96-1
Molecular Formula:C21H23N3O2
Molecular Weight:349.42600
Hs Code.:
Mol file:544681-96-1.mol

Synonyms:4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-;

Suppliers and Price of 4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-

Chemical Property:

PSA：58.37000
LogP:4.82150

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-

There total 3 articles about 4-Isoxazolecarboxamide, N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1136-45-4
5-methyl-3-phenylisoxazol-4-carboxylic acid

: 93-05-0
N,N-diethylaniline

: 544681-96-1
N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide

Guidance literature:: 5-methyl-3-phenylisoxazol-4-carboxylic acid; N,N-diethylaniline; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at -10 - 0 ℃; for 0.166667h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -10 - 0 ℃; for 2.5h;
DOI:10.1021/acs.jmedchem.7b00816

Reference yield:

: 1143-82-4
ethyl 5-methyl-3-phenylisoxazole-4-carboxylate

: 544681-96-1
N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. NaOH / methanol

2: TBTU; DIPEA / dimethylformamide / 20 °C

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.11.075

Reference yield:

: 698-16-8
benzohydroximoyl chloride

: 544681-96-1
N-[4-(diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: NaOMe / methanol / 20 °C

2: 100 percent / aq. NaOH / methanol

3: TBTU; DIPEA / dimethylformamide / 20 °C

With sodium hydroxide; sodium methylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.11.075