Chloromethyl-4-prop-2-ynyloxy-benzene

Base Information

Chemical Name:Chloromethyl-4-prop-2-ynyloxy-benzene
CAS No.:54589-55-8
Molecular Formula:C10H9ClO
Molecular Weight:180.634
Hs Code.:
DSSTox Substance ID:DTXSID501256110

Synonyms:54589-55-8;SCHEMBL3452132;WBCKYDVEAGWDAG-UHFFFAOYSA-N;DTXSID501256110;chloromethyl-4-prop-2-ynyloxy-benzene;4-(2-propyn-1-yloxy)phenylmethyl chloride;1-(Chloromethyl)-4-(2-propyn-1-yloxy)benzene

Suppliers and Price of Chloromethyl-4-prop-2-ynyloxy-benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Chloromethyl-4-prop-2-ynyloxy-benzene

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:180.0341926
Heavy Atom Count:12
Complexity:162

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CCOC1=CC=C(C=C1)CCl

Technology Process of Chloromethyl-4-prop-2-ynyloxy-benzene

There total 6 articles about Chloromethyl-4-prop-2-ynyloxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 34905-02-7
[4-(prop-2-yn-1-yloxy)phenyl]methanol

: 54589-55-8
1-(chloromethyl)-4-(2-propynyloxy)benzene

Guidance literature:: With 1,3,5-trichloro-2,4,6-triazine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/chem.201803725

Reference yield:

: 61747-71-5
2-propynyl 4-(2-propynyloxy)benzoate

: 54589-55-8
1-(chloromethyl)-4-(2-propynyloxy)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h

2: triethylamine / CH₂Cl₂ / 0.5 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo952054a

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 54589-55-8
1-(chloromethyl)-4-(2-propynyloxy)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / K₂CO₃ / toluene; dimethylformamide / 24 h / Ambient temperature

2: 85 percent / lithium aluminum hydride / tetrahydrofuran / 0.5 h

3: triethylamine / CH₂Cl₂ / 0.5 h

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo952054a