7-methyl-2,3-diphenyl-1H-indole

Base Information

• Chemical Name: 7-methyl-2,3-diphenyl-1H-indole
• CAS No.: 54879-93-5
• Molecular Formula: C21H17N
• Molecular Weight: 283.373
• DSSTox Substance ID: DTXSID20543040
• Nikkaji Number: J3.343.320D
• Wikidata: Q82419865
• Mol file: 54879-93-5.mol

Synonyms:7-methyl-2,3-diphenyl-1H-indole;54879-93-5;Oprea1_011016;DTXSID20543040;AKOS002336999;NCGC00327385-01;AB01322322-02

Chemical Property of 7-methyl-2,3-diphenyl-1H-indole

Chemical Property:

• XLogP3: 5.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 283.136099547
• Heavy Atom Count: 22
• Complexity: 353

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=CC=C1)C(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 7-methyl-2,3-diphenyl-1H-indole

There total 15 articles about 7-methyl-2,3-diphenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diphenyl acetylene (501-65-5) + 1-tert-butoxycarbonyl-2-(2-methylphenyl)hydrazine (380383-86-8) → 7-methyl-2,3-diphenyl-1H-indole (54879-93-5)

Guidance literature:

With silver hexafluoroantimonate; carbonyl(η-5-cyclopentadienyl)diiodocobalt(III); potassium acetate; at 80 ℃; for 22h; regioselective reaction; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201510705

Reference yield: 93.0%

7-methyl-2,3-diphenyl-1-(pyrimidin-2-yl)-1H-indole (1355058-39-7) → 7-methyl-2,3-diphenyl-1H-indole (54879-93-5)

Guidance literature:

With sodium ethanolate; In dimethyl sulfoxide; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol203309y

Reference yield: 90.0%

o-tolylhydrazine hydrochloride (635-26-7) + diphenyl acetylene (501-65-5) → 7-methyl-2,3-diphenyl-1H-indole (54879-93-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium acetate; isobutyraldehyde; In methanol; at 80 ℃; for 16h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201304302

upstream raw materials:

o-toluidine hydrochloride

2-hydroxy-2-phenylacetophenone

o-toluidine

1,2-diphenyl-2-(phenylamino)ethanone