Ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate

Base Information

• Chemical Name: Ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate
• CAS No.: 55149-36-5
• Molecular Formula: C10H9N3O3
• Molecular Weight: 219.2
• Hs Code.: 2933990090
• Mol file: 55149-36-5.mol

Synonyms:4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidine-2-carboxylic acid ethyl ester;Ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate;

Chemical Property of Ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate

Chemical Property:

• PSA: 84.94000
• Density: 1.45g/cm3
• LogP: 0.49480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate

There total 3 articles about Ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

ethyl 4-oxo-3,4-dihydropyrido[2,3-d]-1,3-oxazine-2-carboxylate (869299-07-0) → ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate (55149-36-5)

Guidance literature:

With ammonium acetate; acetic acid; In ethanol; for 1h; Reflux;

DOI:10.1016/j.bmc.2014.07.025

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) → ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate (55149-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 3 h / 0 - 50 °C

2: acetic acid; ammonium acetate / ethanol / 1 h / Reflux

With pyridine; ammonium acetate; acetic acid; In ethanol;

DOI:10.1016/j.bmc.2014.07.025

Reference yield:

→ ethyl 4-oxo-3,4-dihydropyrido[2,3-d]pyrimidine-2-carboxylate (55149-36-5)

Guidance literature:

2-Aminonicotinamid,Diethyloxalat;

DOI:10.1021/jm00187a011

upstream raw materials:

2-aminopyridin-3-carboxylic acid

ethyl 4-oxo-3,4-dihydropyrido[2,3-d]-1,3-oxazine-2-carboxylate

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