6-(1-Piperidinyl)-3-pyridinamine

Base Information

• Chemical Name: 6-(1-Piperidinyl)-3-pyridinamine
• CAS No.: 55403-29-7
• Molecular Formula: C10H15N3
• Molecular Weight: 177.249
• Hs Code.: 2933990090
• European Community (EC) Number: 851-188-3
• DSSTox Substance ID: DTXSID40437139
• Wikidata: Q82252520
• Mol file: 55403-29-7.mol

Synonyms:55403-29-7;6-piperidin-1-ylpyridin-3-amine;6-(1-PIPERIDINYL)-3-PYRIDINAMINE;6-(piperidin-1-yl)pyridin-3-amine;MFCD06447399;3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine;SCHEMBL922771;DTXSID40437139;WONYQZCHGNGJRW-UHFFFAOYSA-N;6-PIPERIDINO-3-PYRIDINAMINE;STK352641;AKOS000264522;SB41334;TS-02471;CS-0134708;FT-0681416;EN300-26544

Chemical Property of 6-(1-Piperidinyl)-3-pyridinamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 385.362oC at 760 mmHg
• Flash Point: 186.86oC
• PSA: 42.15000
• Density: 1.128g/cm3
• LogP: 2.30030
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.126597491
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

6-piperidin-1-ylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=NC=C(C=C2)N

Technology Process of 6-(1-Piperidinyl)-3-pyridinamine

There total 8 articles about 6-(1-Piperidinyl)-3-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-nitro-2-piperidinopyridine (26820-61-1) → 3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine (55403-29-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1021/acs.orglett.0c02320

Reference yield: 98.0%

→ 3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine (55403-29-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 19h; Inert atmosphere;

Reference yield:

1,1-diphenyl-N-(6-(piperidin-1-yl)pyridin-3-yl)methanimine → 3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine (55403-29-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 22 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.8b00646

upstream raw materials:

5-nitro-2-piperidinopyridine

2-chloro-5-nitropyridine

piperidine

5-bromo-2-chloropyridine

Downstream raw materials:

(3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-yl)-carbamic acid phenyl ester