2,3-Diphenyl-4'-beta-pyrrolidinoethoxyacrylophenone

Base Information

• Chemical Name: 2,3-Diphenyl-4'-beta-pyrrolidinoethoxyacrylophenone
• CAS No.: 17575-63-2
• Molecular Formula: C27H27NO2
• Molecular Weight: 397.5088
• Nikkaji Number: J73.360A
• ChEMBL ID: CHEMBL147272

Synonyms:2,3-Diphenyl-4'-beta-pyrrolidinoethoxyacrylophenone;2,3-Diphenyl-4'-(2-(1-pyrrolidinyl)ethoxy)acrylophenone;ACRYLOPHENONE, 2,3-DIPHENYL-4'-(2-(1-PYRROLIDINYL)ETHOXY)-;17575-63-2;CHEMBL147272;C27H27NO2;alpha,beta-Diphenyl-4'-[2-(1-pyrrolidinyl)ethoxy]acrylophenone

Chemical Property of 2,3-Diphenyl-4'-beta-pyrrolidinoethoxyacrylophenone

Chemical Property:

• Vapor Pressure: 5.83E-13mmHg at 25°C
• Boiling Point: 569°Cat760mmHg
• Flash Point: 297.9°C
• Density: 1.141g/cm³
• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 397.204179104
• Heavy Atom Count: 30
• Complexity: 545

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)CCOC2=CC=C(C=C2)C(=O)C(=CC3=CC=CC=C3)C4=CC=CC=C4
• Isomeric SMILES: C1CCN(C1)CCOC2=CC=C(C=C2)C(=O)/C(=C/C3=CC=CC=C3)/C4=CC=CC=C4

Technology Process of 2,3-Diphenyl-4'-beta-pyrrolidinoethoxyacrylophenone

There total 3 articles about 2,3-Diphenyl-4'-beta-pyrrolidinoethoxyacrylophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-Hydroxyphenyl)-2-phenylethanone (2491-32-9) → (Z)-2,3-Diphenyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-propenone (94348-30-8,17575-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid, piperidine / benzene / Heating

2: K₂CO₃ / acetone / Heating

With piperidine; potassium carbonate; acetic acid; In acetone; benzene;

DOI:10.1021/jm00382a019

Reference yield:

1-(4-hydroxyphenyl)-2,3-diphenyl-2-propen-1-one (63645-39-6) + 1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) → (E)-1-<4-<2-(1-pyrrolidinyl)ethoxy>phenyl>-2,3-diphenyl-2-propen-1-one (94348-29-5,17575-63-2)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/jm00382a019

Reference yield:

1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) + (Z)-1-(4-Hydroxy-phenyl)-2,3-diphenyl-propenone (94348-28-4) → (Z)-2,3-Diphenyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-propenone (94348-30-8,17575-63-2)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1021/jm00382a019

upstream raw materials:

1-(4-hydroxyphenyl)-2,3-diphenyl-2-propen-1-one

1-(2-chloroethyl)pyrrolidine hydrochloride

(Z)-1-(4-Hydroxy-phenyl)-2,3-diphenyl-propenone

1-(4-Hydroxyphenyl)-2-phenylethanone

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