Pentanoic acid, 2-[(1R)-1-hydroxy-2-(phenylmethoxy)ethyl]-4-methyl-, (1R,2S)-2,3-dihydro-1-[[(4-methylphenyl)sulfonyl]amino]-1H-inden-2-yl ester, (2R)-

Base Information

• Chemical Name: Pentanoic acid, 2-[(1R)-1-hydroxy-2-(phenylmethoxy)ethyl]-4-methyl-, (1R,2S)-2,3-dihydro-1-[[(4-methylphenyl)sulfonyl]amino]-1H-inden-2-yl ester, (2R)-
• CAS No.: 557111-29-2
• Molecular Formula: C31H37NO6S
• Molecular Weight: 551.704
• Mol file: 557111-29-2.mol

Synonyms:

Chemical Property of Pentanoic acid, 2-[(1R)-1-hydroxy-2-(phenylmethoxy)ethyl]-4-methyl-, (1R,2S)-2,3-dihydro-1-[[(4-methylphenyl)sulfonyl]amino]-1H-inden-2-yl ester, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanoic acid, 2-[(1R)-1-hydroxy-2-(phenylmethoxy)ethyl]-4-methyl-, (1R,2S)-2,3-dihydro-1-[[(4-methylphenyl)sulfonyl]amino]-1H-inden-2-yl ester, (2R)-

There total 3 articles about Pentanoic acid, 2-[(1R)-1-hydroxy-2-(phenylmethoxy)ethyl]-4-methyl-, (1R,2S)-2,3-dihydro-1-[[(4-methylphenyl)sulfonyl]amino]-1H-inden-2-yl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzyloxyacetoaldehyde (60656-87-3) + (1R,2S)-cis-N-[2,3-dihydro-2-(4-methyl-1-oxopentyloxy)inden-1-yl]-4-methylbenzenesulfonamide (557111-28-1) → (1R,2S)-cis-N-(2,3-dihydro-2-[(2R,3R)-3-hydroxy-2-(isobutyl)-4-(phenylmethoxy)-1-oxobutoxy]inden-1-yl)-4-methylbenzenesulfonamide (557111-29-2)

Guidance literature:

With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;

DOI:10.1021/jo030063a

Reference yield:

4-Methylpentanoic acid (646-07-1) → (1R,2S)-cis-N-(2,3-dihydro-2-[(2R,3R)-3-hydroxy-2-(isobutyl)-4-(phenylmethoxy)-1-oxobutoxy]inden-1-yl)-4-methylbenzenesulfonamide (557111-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / DMAP; DIEA; diisopropylcarbodiimide / CHCl₃ / 25 °C

2: 94 percent / TiCl₄; DIEA / CH₂Cl₂ / -78 °C

With dmap; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In dichloromethane; chloroform;

DOI:10.1021/jo030063a

Reference yield:

(+)-(1R,2S)-1-(N-tosylamino)-2-indanol (175523-35-0) → (1R,2S)-cis-N-(2,3-dihydro-2-[(2R,3R)-3-hydroxy-2-(isobutyl)-4-(phenylmethoxy)-1-oxobutoxy]inden-1-yl)-4-methylbenzenesulfonamide (557111-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / DMAP; DIEA; diisopropylcarbodiimide / CHCl₃ / 25 °C

2: 94 percent / TiCl₄; DIEA / CH₂Cl₂ / -78 °C

With dmap; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In dichloromethane; chloroform;

DOI:10.1021/jo030063a

upstream raw materials:

benzyloxyacetoaldehyde

(1R,2S)-cis-N-[2,3-dihydro-2-(4-methyl-1-oxopentyloxy)inden-1-yl]-4-methylbenzenesulfonamide

4-Methylpentanoic acid

(+)-(1R,2S)-1-(N-tosylamino)-2-indanol

Downstream raw materials:

(4R,5R)-4-isobutyl-5-[(phenylmethyloxy)methyl]oxazolidin-2-one