4-Hydroxyglibenclamide

Base Information

• Chemical Name: 4-Hydroxyglibenclamide
• CAS No.: 23155-04-6
• Molecular Formula: C₂₃H₂₈ClN₃O₆S
• Molecular Weight: 510.011
• UNII: 8J8OD7PL2J
• DSSTox Substance ID: DTXSID10177737,DTXSID601308718
• Nikkaji Number: J409.106J,J2.945.115J
• Wikidata: Q27270623
• ChEMBL ID: CHEMBL575837
• Mol file: 23155-04-6.mol

Synonyms:4-hydroxyglibenclamide;4-hydroxyglibenclamide, (trans)-isomer

Chemical Property of 4-Hydroxyglibenclamide

Chemical Property:

• Melting Point: 180-184°C
• Boiling Point: °Cat760mmHg
• PKA: 5.08±0.10(Predicted)
• Flash Point: °C
• PSA: 142.21000
• Density: 1.41g/cm³
• LogP: 4.86600
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 509.1387345
• Heavy Atom Count: 34
• Complexity: 776

Purity/Quality:

97% ^*data from raw suppliers

RAC-TRANS-4-HYDROXYGLYBURIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)O
• Uses: 4-Hydroxyglibenclamide is a metabolite of Glyburide which is used as an antidiabetic.

Technology Process of 4-Hydroxyglibenclamide

There total 1 articles about 4-Hydroxyglibenclamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-Hydroxyglibenclamide (23155-00-2,132054-81-0,23155-04-6)

Guidance literature:

25, S.griseolus (mikrobiologisch) im Fermenter;