1H-Pyrazole-3-acetamide, 5-[[7-(3-chloropropoxy)-6-methoxy-4-quinazolinyl]amino]-N-(2,3-difluoro phenyl)-

Base Information

• Chemical Name: 1H-Pyrazole-3-acetamide, 5-[[7-(3-chloropropoxy)-6-methoxy-4-quinazolinyl]amino]-N-(2,3-difluoro phenyl)-
• CAS No.: 557769-44-5
• Molecular Formula: C23H21ClF2N6O3
• Molecular Weight: 502.908
• Mol file: 557769-44-5.mol

Synonyms:

Chemical Property of 1H-Pyrazole-3-acetamide, 5-[[7-(3-chloropropoxy)-6-methoxy-4-quinazolinyl]amino]-N-(2,3-difluoro phenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrazole-3-acetamide, 5-[[7-(3-chloropropoxy)-6-methoxy-4-quinazolinyl]amino]-N-(2,3-difluoro phenyl)-

There total 3 articles about 1H-Pyrazole-3-acetamide, 5-[[7-(3-chloropropoxy)-6-methoxy-4-quinazolinyl]amino]-N-(2,3-difluoro phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(5-((7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl)amino)-1H-pyrazol-3-yl)acetic acid (557769-40-1) + 2,3-difluoroanilline (4519-40-8) → 2-(5-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(2,3-difluorophenyl)acetamide (557769-44-5)

Guidance literature:

(5-((7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl)amino)-1H-pyrazol-3-yl)acetic acid; 2,3-difluoroanilline; With pyridine; trichlorophosphate; In ethyl acetate; at 0 - 20 ℃; for 1.5h;

With ammonia; In water; at 0 ℃; for 0.25h; pH=7;

Reference yield: 50.0%

(5-((7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl)amino)-2H-pyrazol-3-yl)acetic acid (557769-40-1) + 2,3-difluoroanilline (4519-40-8) → 2-(5-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(2,3-difluorophenyl)acetamide (557769-44-5)

Guidance literature:

With pyridine; trichlorophosphate; In ethyl acetate; at 0 - 20 ℃; for 1.5h;

DOI:10.1021/jm061335f

Reference yield:

(5-amino-2H-pyrazol-3-yl)acetic acid (174891-10-2) → 2-(5-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(2,3-difluorophenyl)acetamide (557769-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / AcOH / 1.5 h / Heating

2: 50 percent / pyridine; phosphorus oxychloride / ethyl acetate / 1.5 h / 0 - 20 °C

With pyridine; acetic acid; trichlorophosphate; In ethyl acetate; 1: Dimroth cyclization;

DOI:10.1021/jm061335f

upstream raw materials:

(5-((7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl)amino)-2H-pyrazol-3-yl)acetic acid

2,3-difluoroanilline

(5-amino-2H-pyrazol-3-yl)acetic acid

(5-((7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl)amino)-1H-pyrazol-3-yl)acetic acid

Downstream raw materials:

N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide

N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(propyl)amino]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide

di-tert-butyl 2-[[3-({4-[(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl](propyl)amino]ethyl phosphate

di-tert-butyl {(2R)-1-[3-({4-[(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]pyrrolidin-2-yl}methyl phosphate