Technology Process of Carbamic acid, [(1S)-1-methyl-5-methylene-8-oxododecyl]-,
phenylmethyl ester
There total 5 articles about Carbamic acid, [(1S)-1-methyl-5-methylene-8-oxododecyl]-,
phenylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-(1-methyl-but-3-enyl)-carbamic acid benzyl ester;
With
9-borabicyclo[3.3.1]nonane dimer;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
2-iodo-5-oxo-1-nonene;
With
triphenyl-arsane; caesium carbonate;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
at 20 ℃;
for 6h;
DOI:10.1021/jo030083c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 97 percent / Et3N; DMAP / CH2Cl2 / 20 °C
2.1: 69 percent / NaI; TMSCl / acetonitrile; H2O / 1 h / 20 °C
3.1: 81 percent / NaOMe / methanol / 20 °C
4.1: 83 percent / pyridinium dichromate; molecular sieves 4 Angstroem / CH2Cl2 / 20 °C
5.1: 9-BBN-H / tetrahydrofuran / 2 h / 20 °C
5.2: 76 percent / Cs2CO3; AsPh3 / tetrahydrofuran; H2O; dimethylformamide / 6 h / 20 °C
With
dmap; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; chloro-trimethyl-silane; 4 A molecular sieve; sodium methylate; triethylamine; sodium iodide;
In
tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
5.2: Suzuki cross coupling;
DOI:10.1021/jo030083c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 83 percent / pyridinium dichromate; molecular sieves 4 Angstroem / CH2Cl2 / 20 °C
2.1: 9-BBN-H / tetrahydrofuran / 2 h / 20 °C
2.2: 76 percent / Cs2CO3; AsPh3 / tetrahydrofuran; H2O; dimethylformamide / 6 h / 20 °C
With
dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; 4 A molecular sieve;
In
tetrahydrofuran; dichloromethane;
2.2: Suzuki cross coupling;
DOI:10.1021/jo030083c
