2-cyclopropylpyrrolidine hcl

Base Information

• Chemical Name: 2-cyclopropylpyrrolidine hcl
• CAS No.: 558478-81-2
• Molecular Formula: C7H13N.ClH
• Molecular Weight: 147.648
• Mol file: 558478-81-2.mol

Synonyms:2-cyclopropylpyrrolidine hydrochloride;2-CYCLOPROPYLPYRROLIDINE HCL;2-cyclopropylpyrrolidine monohydrochloride;

Chemical Property of 2-cyclopropylpyrrolidine hcl

Chemical Property:

• PSA: 12.03000
• LogP: 2.27920

Purity/Quality:

99% ^*data from raw suppliers

2-cyclopropylpyrrolidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-cyclopropylpyrrolidine hcl

There total 1 articles about 2-cyclopropylpyrrolidine hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,4-di-tert-butyl-6-(2-cyclopropylpyrrolidin-1-yl)phenol → 2-cyclopropylpyrrolidine hydrochloride (558478-81-2) + 3,5-di-tert-butyl-o-benzoquinone (3383-21-9)

Guidance literature:

2,4-di-tert-butyl-6-(2-cyclopropylpyrrolidin-1-yl)phenol; With water; iodine; potassium carbonate; In dichloromethane; 2,2,2-trifluoroethanol;

With hydrogenchloride; In water; Solvent;

DOI:10.1021/acs.joc.7b00361

Reference yield:

2-cyclopropylpyrrolidine hydrochloride (558478-81-2) + 3,5-di-tert-butyl-o-benzoquinone (3383-21-9) → 5-cyclopropyl-1-(3,5-di-tert-butyl-2-hydroxyphenyl)pyrrolidin-2-one

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 2,2,2-trifluoroethanol / 0.5 h / 20 °C

2: 3,5-di-tert-butyl-o-benzoquinone; water / 24 h / 50 °C

With 3,5-di-tert-butyl-o-benzoquinone; water; potassium carbonate; In 2,2,2-trifluoroethanol;

DOI:10.1021/acs.joc.6b02562

Refernces