2,8-Decadienoic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,8-dimethyl-10-oxo-5-[2-(phenyl methoxy)ethyl]-, ethyl ester, (2E,5R,6R)-

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Chemical Name:2,8-Decadienoic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,8-dimethyl-10-oxo-5-[2-(phenyl methoxy)ethyl]-, ethyl ester, (2E,5R,6R)-
CAS No.:561063-83-0
Molecular Formula:C29H46O5Si
Molecular Weight:502.767
Hs Code.:

Synonyms:

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Chemical Property of 2,8-Decadienoic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,8-dimethyl-10-oxo-5-[2-(phenyl methoxy)ethyl]-, ethyl ester, (2E,5R,6R)-

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Technology Process of 2,8-Decadienoic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,8-dimethyl-10-oxo-5-[2-(phenyl methoxy)ethyl]-, ethyl ester, (2E,5R,6R)-

There total 15 articles about 2,8-Decadienoic acid, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,8-dimethyl-10-oxo-5-[2-(phenyl methoxy)ethyl]-, ethyl ester, (2E,5R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 561063-82-9
(E)-(5R,6R)-5-(2-Benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-2,8-dimethyl-deca-2,9-dienoic acid ethyl ester

: 561063-83-0
(2E,8E)-(5R,6R)-5-(2-Benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-2,8-dimethyl-10-oxo-deca-2,8-dienoic acid ethyl ester

Guidance literature:: With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; at 20 ℃;

Reference yield:

: 128355-20-4
(3R,4S)-3-tert-butyloxycarbonylmethyl-4-hydroxy-5-tetrahydropyranyloxypentanoic acid γ-lactone

: 561063-83-0
(2E,8E)-(5R,6R)-5-(2-Benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-2,8-dimethyl-10-oxo-deca-2,8-dienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 15 steps

1.1: 87 percent / DIBALH / tetrahydrofuran / -78 °C

2.1: 99 percent / (+/-)-CSA / 50 °C

3.1: Et₃N; DMAP / dimethylformamide / 0 - 20 °C

4.1: LiAlH₄ / diethyl ether / 0 - 20 °C

5.1: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

6.1: TBAF / tetrahydrofuran / 20 °C

7.1: Et₃N / CH₂Cl₂ / 0 °C

8.1: NaI / acetone / Heating

9.1: BuLi / tetrahydrofuran / -78 - 20 °C

9.2: tetrahydrofuran / -78 - 20 °C

10.1: (+/-)-CSA / methanol; H₂O / 60 °C

11.1: 72 percent / diethyl ether / -78 °C

12.1: aq. AcOH / 60 °C

13.1: 1,2-dichloro-ethane / 80 °C

14.1: 68 percent / Et₃N; DMAP / dimethylformamide / 40 °C

15.1: 87 percent / PDC; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

With dmap; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; 10-camphorsufonic acid; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; acetic acid; triethylamine; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 13.1: Wittig reaction;

Reference yield:

: 561063-79-4
[(2S,3R)-5-Hydroxy-2-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-3-yl]-acetic acid tert-butyl ester

: 561063-83-0
(2E,8E)-(5R,6R)-5-(2-Benzyloxy-ethyl)-6-(tert-butyl-dimethyl-silanyloxy)-2,8-dimethyl-10-oxo-deca-2,8-dienoic acid ethyl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: 99 percent / (+/-)-CSA / 50 °C

2.1: Et₃N; DMAP / dimethylformamide / 0 - 20 °C

3.1: LiAlH₄ / diethyl ether / 0 - 20 °C

4.1: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

5.1: TBAF / tetrahydrofuran / 20 °C

6.1: Et₃N / CH₂Cl₂ / 0 °C

7.1: NaI / acetone / Heating

8.1: BuLi / tetrahydrofuran / -78 - 20 °C

8.2: tetrahydrofuran / -78 - 20 °C

9.1: (+/-)-CSA / methanol; H₂O / 60 °C

10.1: 72 percent / diethyl ether / -78 °C

11.1: aq. AcOH / 60 °C

12.1: 1,2-dichloro-ethane / 80 °C

13.1: 68 percent / Et₃N; DMAP / dimethylformamide / 40 °C

14.1: 87 percent / PDC; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

With dmap; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; 4 A molecular sieve; 10-camphorsufonic acid; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; triethylamine; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 12.1: Wittig reaction;