Benzoic acid, 2-[(1E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]-, ethyl ester

Base Information

Chemical Name:Benzoic acid, 2-[(1E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]-, ethyl ester
CAS No.:561066-97-5
Molecular Formula:C22H27NO2
Molecular Weight:337.462
Hs Code.:

Synonyms:2-[(E)-2-(4-Diethylaminomethyl-phenyl)-vinyl]-benzoic acid ethyl ester;

Suppliers and Price of Benzoic acid, 2-[(1E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Benzoic acid, 2-[(1E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]-, ethyl ester

Chemical Property:

PSA：29.54000
LogP:4.87550

Purity/Quality:: 98%Min ^*data from raw suppliers

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Technology Process of Benzoic acid, 2-[(1E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]-, ethyl ester

There total 1 articles about Benzoic acid, 2-[(1E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 3749-75-5
N-(4-vinylbenzyl)-N,N-diethylamine

: 6091-64-1
2-bromobenzoic acid ethyl ester

: 561066-97-5
2-[E-2-(4-diethylaminomethylphenyl)ethen-1-yl]benzoic acid ethyl ester

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In water; N,N-dimethyl-formamide; at 100 ℃; for 3h;
DOI:10.1021/jm0210717

Reference yield: 87.0%

: 561066-97-5
2-[E-2-(4-diethylaminomethylphenyl)ethen-1-yl]benzoic acid ethyl ester

: 561066-99-7
2-[E-2-(4-diethylaminomethylphenyl)ethen-1-yl]benzoic acid

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; for 12h; Heating;
DOI:10.1021/jm0210717

Reference yield:

: 561066-97-5
2-[E-2-(4-diethylaminomethylphenyl)ethen-1-yl]benzoic acid ethyl ester

: N-(1-benzyl-2-carbamoyl-2-oxo-ethyl)-2-[(E)-2-(4-diethylaminomethylphenyl)vinyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / aq. KOH / tetrahydrofuran / 12 h / Heating

2: 72 percent / HOBt; Et₃N; EDC / dimethylformamide / 16 h / 20 °C

3: DCC; Cl₂CHCOOH; DMSO / CH₂Cl₂ / 1 h

With dichloro-acetic acid; potassium hydroxide; benzotriazol-1-ol; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0210717