cis-(4-Hydroxy-cyclohexyl)-Methyl-carbaMic acid tert-butyl ester

Base Information

• Chemical Name: cis-(4-Hydroxy-cyclohexyl)-Methyl-carbaMic acid tert-butyl ester
• CAS No.: 561307-54-8
• Molecular Formula: C12H23NO3
• Molecular Weight: 229.32
• Mol file: 561307-54-8.mol

Synonyms:cis-(4-hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester;cis-(4-hydroxycyclohexyl)methylcarbamic acid tert-butyl ester;TERT-BUTYL (1S,4S)-4-HYDROXYCYCLOHEXYL(METHYL)CARBAMATE;

Chemical Property of cis-(4-Hydroxy-cyclohexyl)-Methyl-carbaMic acid tert-butyl ester

Chemical Property:

• Boiling Point: 319.2±31.0 °C(Predicted)
• PKA: 15.09±0.40(Predicted)
• PSA: 49.77000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 2.15680

Purity/Quality:

97% ^*data from raw suppliers

cis-(4-Hydroxy-cyclohexyl)-methyl-carbamicacidtert-butylester 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-(4-Hydroxy-cyclohexyl)-Methyl-carbaMic acid tert-butyl ester

There total 3 articles about cis-(4-Hydroxy-cyclohexyl)-Methyl-carbaMic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + cis-4-Methylamino-cyclohexanol-(1) (22348-38-5) → tert-butyl methyl(4-oxocyclohexyl)carbamate (561307-54-8)

Guidance literature:

With sodium hydrogencarbonate; In methanol; at 40 ℃; for 3h;

Reference yield:

benzoic acid 4-cis-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl ester (1332632-63-9) → tert-butyl methyl(4-oxocyclohexyl)carbamate (561307-54-8)

Guidance literature:

benzoic acid 4-cis-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl ester; With potassium carbonate; In methanol; at 20 ℃;

With sodium hydroxide; In methanol; water; for 4h;

Reference yield:

tert-butyl ((1r,4r)-4-hydroxycyclohexyl)(methyl)carbamate (400899-99-2) → tert-butyl methyl(4-oxocyclohexyl)carbamate (561307-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2.17 h

2.1: potassium carbonate / methanol / 20 °C

2.2: 4 h

With potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

upstream raw materials:

di-tert-butyl dicarbonate

cis-4-Methylamino-cyclohexanol-⁽¹⁾

tert-butyl ((1r,4r)-4-hydroxycyclohexyl)(methyl)carbamate

benzoic acid 4-cis-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl ester

Downstream raw materials:

cis-1-methanesulphonyloxy-4-[N-(tert-butyloxycarbonyl)-N-methyl-amino]-cyclohexane

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