2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-, (3S)-

Base Information

Chemical Name:2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-, (3S)-
CAS No.:562817-53-2
Molecular Formula:C13H15NO4
Molecular Weight:249.266
Hs Code.:

Synonyms:(S)-3-Hydroxy-1-(4-methoxy-benzyl)-piperidine-2,6-dione;N-(p-methoxybenzyl)-3-hydroxyglutarimide;(S)-3-hydroxy-1-(4-methoxybenzyl)-2,6-piperidinedione;

Suppliers and Price of 2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-, (3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-, (3S)-

Chemical Property:

PSA：66.84000
LogP:0.64300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-, (3S)-

There total 3 articles about 2,6-Piperidinedione, 3-hydroxy-1-[(4-methoxyphenyl)methyl]-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 562817-52-1
(S)-N-(4-methoxybenzyl)-tetrahydro-5-oxo-2-furancarboxamide

: 562817-53-2
(3S)-1-(4-methoxybenzyl)-3-hydroxypiperidine-2,6-dione

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -78 - -40 ℃; for 1h;
DOI:10.1021/ol034505g

Reference yield:

: 21461-84-7
(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

: 562817-53-2
(3S)-1-(4-methoxybenzyl)-3-hydroxypiperidine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 5 h / Heating

2: 8.380 g / triethylamine / CH₂Cl₂ / 3 h / 20 °C

3: 90 percent / potassium tert-butoxide / tetrahydrofuran / 1 h / -78 - -40 °C

With thionyl chloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol034505g

Reference yield:

: 54848-33-8
(S)-tetrahydro-5-oxo-2-furancarbonyl chloride

: 562817-53-2
(3S)-1-(4-methoxybenzyl)-3-hydroxypiperidine-2,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 8.380 g / triethylamine / CH₂Cl₂ / 3 h / 20 °C

2: 90 percent / potassium tert-butoxide / tetrahydrofuran / 1 h / -78 - -40 °C

With potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol034505g