Technology Process of 1-Piperidinecarboxylic acid, 3-(hydroxyimino)-2-phenyl-,
1,1-dimethylethyl ester, (2S)-
There total 5 articles about 1-Piperidinecarboxylic acid, 3-(hydroxyimino)-2-phenyl-,
1,1-dimethylethyl ester, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; potassium carbonate;
In
dichloromethane;
at -20 ℃;
for 5h;
DOI:10.1021/ol034505g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / H2 / Pd(OH)2/C / ethanol / 72 h / 20 °C
2: oxalyl chloride; dimethylsulfoxide; diisopropylethylamine / CH2Cl2 / -78 - -20 °C
3: 430 mg / hydroxylamine hydrochloride; potassium carbonate / CH2Cl2 / 5 h / -20 °C
With
oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
palladium dihydroxide;
In
ethanol; dichloromethane;
2: Swern oxidation;
DOI:10.1021/ol034505g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 20 °C
2: 88 percent / H2 / Pd(OH)2/C / ethanol / 72 h / 20 °C
3: oxalyl chloride; dimethylsulfoxide; diisopropylethylamine / CH2Cl2 / -78 - -20 °C
4: 430 mg / hydroxylamine hydrochloride; potassium carbonate / CH2Cl2 / 5 h / -20 °C
With
lithium aluminium tetrahydride; oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane;
3: Swern oxidation;
DOI:10.1021/ol034505g
