1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-[(2S,4S,5S)-5-(1Z)-1-butenyl-2-methyl-1,3-dioxolan-4-yl]-3-methyl-8-( phenylmethylene)-9-[[tris(1-methylethyl)silyl]oxy]-, (5S,8Z,9S)-

Base Information

Chemical Name:1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-[(2S,4S,5S)-5-(1Z)-1-butenyl-2-methyl-1,3-dioxolan-4-yl]-3-methyl-8-( phenylmethylene)-9-[[tris(1-methylethyl)silyl]oxy]-, (5S,8Z,9S)-
CAS No.:562858-34-8
Molecular Formula:C32H45NO6Si
Molecular Weight:567.798
Hs Code.:

1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione,
2-[(2S,4S,5S)-5-(1Z)-1-butenyl-2-methyl-1,3-dioxolan-4-yl]-3-methyl-8-(
phenylmethylene)-9-[[tris(1-methylethyl)silyl]oxy]-, (5S,8Z,9S)-

Synonyms:

Suppliers and Price of 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-[(2S,4S,5S)-5-(1Z)-1-butenyl-2-methyl-1,3-dioxolan-4-yl]-3-methyl-8-( phenylmethylene)-9-[[tris(1-methylethyl)silyl]oxy]-, (5S,8Z,9S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-[(2S,4S,5S)-5-(1Z)-1-butenyl-2-methyl-1,3-dioxolan-4-yl]-3-methyl-8-( phenylmethylene)-9-[[tris(1-methylethyl)silyl]oxy]-, (5S,8Z,9S)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-[(2S,4S,5S)-5-(1Z)-1-butenyl-2-methyl-1,3-dioxolan-4-yl]-3-methyl-8-( phenylmethylene)-9-[[tris(1-methylethyl)silyl]oxy]-, (5S,8Z,9S)-

There total 1 articles about 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione, 2-[(2S,4S,5S)-5-(1Z)-1-butenyl-2-methyl-1,3-dioxolan-4-yl]-3-methyl-8-( phenylmethylene)-9-[[tris(1-methylethyl)silyl]oxy]-, (5S,8Z,9S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: (3S,4S)-(Z)-5-benzylidene-3-[3-((2S,4R,5S)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-4-hydroxy-2-methylpropionyl]-3-hydroxy-4-triisopropylsiloxypyrrolidin-2-one

: 562858-34-8
(5S,9S)-(Z)-8-benzylidene-2-((2S,4S,5S)-(Z)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-3-methyl-9-triisopropylsiloxy-1-oxa-7-aza-spiro[4.4]non-2-ene-4,6-dione

: (5S,9S)-(Z)-8-benzylidene-2-((2S,4S,5S)-(E)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-3-methyl-9-triisopropylsiloxy-1-oxa-7-aza-spiro[4.4]non-2-ene-4,6-dione

Guidance literature:: (3S,4S)-(Z)-5-benzylidene-3-[3-((2S,4R,5S)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-4-hydroxy-2-methylpropionyl]-3-hydroxy-4-triisopropylsiloxypyrrolidin-2-one; With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1.08333h;

With silica gel; In hexane; ethyl acetate;

With silica gel; In chloroform; ethyl acetate;
DOI:10.1021/ol034630s

Reference yield: 62.0%

: 562858-34-8
(5S,9S)-(Z)-8-benzylidene-2-((2S,4S,5S)-(Z)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-3-methyl-9-triisopropylsiloxy-1-oxa-7-aza-spiro[4.4]non-2-ene-4,6-dione

: 562858-36-0
(5S,8S,9R)-2-((2S,4S,5S)-(Z)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-8-hydroxy-8-(hydroxyphenylmethyl)-3-methyl-9-triisopropylsiloxy-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione

Guidance literature:: With 4 A molecular sieve; 3,3-dimethyldioxirane; In methanol; at -60 ℃; for 10.5h;
DOI:10.1021/ol034630s

Reference yield:

: 562858-34-8
(5S,9S)-(Z)-8-benzylidene-2-((2S,4S,5S)-(Z)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-3-methyl-9-triisopropylsiloxy-1-oxa-7-aza-spiro[4.4]non-2-ene-4,6-dione

: 562858-39-3
(5S,8S,9R)-8-benzoyl-2-((2S,4S,5S)-(Z)-5-(but-1-enyl)-2-methyl-[1,3]dioxolan-4-yl)-8,9-dihydroxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / dimethyldioxirane; molecular sieves 4 Angstroem / methanol / 10.5 h / -60 °C

2: 68 percent / Dess-Martin periodinane / CH₂Cl₂ / 2.5 h / 20 °C

3: 60 percent / NH₄F / methanol / 2.5 h / 20 °C

With ammonium fluoride; 4 A molecular sieve; 3,3-dimethyldioxirane; Dess-Martin periodane; In methanol; dichloromethane;
DOI:10.1021/ol034630s