Ethyl 4-[(4-chlorophenoxy)methyl]benzoate

Base Information

Chemical Name:Ethyl 4-[(4-chlorophenoxy)methyl]benzoate
CAS No.:56442-34-3
Molecular Formula:C16H15ClO3
Molecular Weight:290.746
Hs Code.:
European Community (EC) Number:657-199-8
ChEMBL ID:CHEMBL3278164

Synonyms:Ethyl 4-[(4-chlorophenoxy)methyl]benzoate;Ethyl 4-((4-chlorophenoxy)methyl)benzoate;Oprea1_605780;CHEMBL3278164;AKOS003651244

Suppliers and Price of Ethyl 4-[(4-chlorophenoxy)methyl]benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-[(4-chlorophenoxy)methyl]benzoate

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:290.0709720
Heavy Atom Count:20
Complexity:292

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CC=C(C=C1)COC2=CC=C(C=C2)Cl

Technology Process of Ethyl 4-[(4-chlorophenoxy)methyl]benzoate

There total 5 articles about Ethyl 4-[(4-chlorophenoxy)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 26496-94-6
Ethyl 4-(bromomethyl)benzoate

: 106-48-9,82344-39-6
4-chloro-phenol

: 56442-34-3
ethyl 4-([4-chlorophenoxy]methyl)benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00551

Reference yield:

: 99-94-5
p-Toluic acid

: 56442-34-3
ethyl 4-([4-chlorophenoxy]methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 1 h / Inert atmosphere; Reflux

3: potassium carbonate / N,N-dimethyl-formamide

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; potassium carbonate; In chloroform; N,N-dimethyl-formamide; 3: |Williamson Ether Synthesis;
DOI:10.1021/acsmedchemlett.8b00551

Reference yield:

: 94-08-6
4-methylbenzoic acid ethyl ester

: 56442-34-3
ethyl 4-([4-chlorophenoxy]methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 1 h / Inert atmosphere; Reflux

2: potassium carbonate / N,N-dimethyl-formamide

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In chloroform; N,N-dimethyl-formamide; 2: |Williamson Ether Synthesis;
DOI:10.1021/acsmedchemlett.8b00551