L-Serine, O-(1,1-dimethyl-2-propenyl)-N-[(2,2,2-trichloro-1,1-dimethylethoxy)carb onyl]-L-seryl-L-isoleucyl-L-alanyl-L-prolyl-L-phenylalanyl-, methyl ester

Base Information

Chemical Name:L-Serine, O-(1,1-dimethyl-2-propenyl)-N-[(2,2,2-trichloro-1,1-dimethylethoxy)carb onyl]-L-seryl-L-isoleucyl-L-alanyl-L-prolyl-L-phenylalanyl-, methyl ester
CAS No.:564489-31-2
Molecular Formula:C₄₀H₅₉Cl₃N₆O₁₁
Molecular Weight:906.301
Hs Code.:

L-Serine,
O-(1,1-dimethyl-2-propenyl)-N-[(2,2,2-trichloro-1,1-dimethylethoxy)carb
onyl]-L-seryl-L-isoleucyl-L-alanyl-L-prolyl-L-phenylalanyl-, methyl ester

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Chemical Property of L-Serine, O-(1,1-dimethyl-2-propenyl)-N-[(2,2,2-trichloro-1,1-dimethylethoxy)carb onyl]-L-seryl-L-isoleucyl-L-alanyl-L-prolyl-L-phenylalanyl-, methyl ester

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Technology Process of L-Serine, O-(1,1-dimethyl-2-propenyl)-N-[(2,2,2-trichloro-1,1-dimethylethoxy)carb onyl]-L-seryl-L-isoleucyl-L-alanyl-L-prolyl-L-phenylalanyl-, methyl ester

There total 9 articles about L-Serine, O-(1,1-dimethyl-2-propenyl)-N-[(2,2,2-trichloro-1,1-dimethylethoxy)carb onyl]-L-seryl-L-isoleucyl-L-alanyl-L-prolyl-L-phenylalanyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 340270-70-4
(S)-3-(1,1-Dimethyl-allyloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-propionic acid

: 791059-68-2
(S)-2-[(S)-2-({(S)-1-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionylamino]-3-hydroxy-propionic acid methyl ester

: 564489-31-2
2-(2-{[1-(2-{2-[3-(1,1-dimethyl-allyloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 43h;
DOI:10.1016/S0040-4020(03)00294-1

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 564489-31-2
2-(2-{[1-(2-{2-[3-(1,1-dimethyl-allyloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 74 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 51 h / 0 - 20 °C

2: acetyl chloride / methanol / 3.5 h / 20 °C

3: 4.50 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 52 h / 0 - 20 °C

4: acetyl chloride / methanol / 3 h / 20 °C

5: 4.12 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 47 h / 0 - 20 °C

6: acetyl chloride / methanol / 4 h / 20 °C

7: 81 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 28 h / 20 °C

8: acetyl chloride / methanol / 3.5 h / 20 °C

9: 397 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 43 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00294-1

Reference yield:

: 34290-59-0
(S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate

: 564489-31-2
2-(2-{[1-(2-{2-[3-(1,1-dimethyl-allyloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: acetyl chloride / methanol / 3.5 h / 20 °C

2: 4.50 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 52 h / 0 - 20 °C

3: acetyl chloride / methanol / 3 h / 20 °C

4: 4.12 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 47 h / 0 - 20 °C

5: acetyl chloride / methanol / 4 h / 20 °C

6: 81 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 28 h / 20 °C

7: acetyl chloride / methanol / 3.5 h / 20 °C

8: 397 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 43 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00294-1