9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine

Base Information

Chemical Name:9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine
CAS No.:160056-49-5
Molecular Formula:C22H40 N6 O4 Si2
Molecular Weight:508.7618
Hs Code.:
Mol file:160056-49-5.mol

Synonyms:

Suppliers and Price of 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine

Chemical Property:

Vapor Pressure:7.85E-13mmHg at 25°C
Boiling Point:566°Cat760mmHg
Flash Point:296.1°C
Density:1.31g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine

There total 6 articles about 9-[9-amino-2,2,4,4-tetrakis(1-methylethyl)tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 88121-26-0
2'?azido?2'?deoxy?3',5'?O?(1,1,3,3?tetraisopropyldisiloxane?1,3?diyl)adenosine

: 160056-49-5
2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 15h; under 0.0006 Torr; Ambient temperature;
DOI:10.1002/hlca.19940770306

Reference yield: 39.0%

: 88121-26-0
2'?azido?2'?deoxy?3',5'?O?(1,1,3,3?tetraisopropyldisiloxane?1,3?diyl)adenosine

: 160056-49-5
2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

: C₂₂H₄₂N₆O₄Si₂

Guidance literature:: With pyridine; ammonium hydroxide; triphenylphosphine; In 1,4-dioxane; water; for 24h;
DOI:10.1002/hlca.19980810556

Reference yield:

: 87792-02-7
9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine

: 160056-49-5
2'-amino-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-adenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / DMAP / CH₂Cl₂ / -50 deg C, 15 min; RT, 45 min

2: 90 percent / LiN₃ / dimethylformamide / 2 h / Ambient temperature

3: 82 percent / Bu₃SnH, AIBN / toluene / 1.5 h / Heating; via Staudinger reduction, too

With dmap; lithium azide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19980810556