Acetamide, N-[4-bromo-2-[[3-bromo-1-(phenylsulfonyl)-1H-indol-2-yl]methyl]-5-meth oxyphenyl]-

Base Information

• Chemical Name: Acetamide, N-[4-bromo-2-[[3-bromo-1-(phenylsulfonyl)-1H-indol-2-yl]methyl]-5-meth oxyphenyl]-
• CAS No.: 565227-62-5
• Molecular Formula: C24H20Br2N2O4S
• Molecular Weight: 592.308
• Mol file: 565227-62-5.mol

Synonyms:

Chemical Property of Acetamide, N-[4-bromo-2-[[3-bromo-1-(phenylsulfonyl)-1H-indol-2-yl]methyl]-5-meth oxyphenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, N-[4-bromo-2-[[3-bromo-1-(phenylsulfonyl)-1H-indol-2-yl]methyl]-5-meth oxyphenyl]-

There total 2 articles about Acetamide, N-[4-bromo-2-[[3-bromo-1-(phenylsulfonyl)-1H-indol-2-yl]methyl]-5-meth oxyphenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-(4-bromo-3-methoxyphenyl)acetamide (104066-80-0) + [3-bromo-1-(phenylsulfonyl)indol-2-yl]methanol (565227-63-6) → N-{4-bromo-2-[(3-bromo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-5-methoxyphenyl}acetamide (565227-62-5)

Guidance literature:

With boron trifluoride diethyl etherate; magnesium sulfate; In chloroform; for 3h; Heating;

DOI:10.1081/SCC-120021513

Reference yield:

3-bromo-2-(bromomethyl)-1-(phenylsulfonyl)-1H-indole (177274-67-8) → N-{4-bromo-2-[(3-bromo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-5-methoxyphenyl}acetamide (565227-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78.4 percent / aq. potassium carbonate / acetonitrile / 5 h / Heating

2: 76 percent / BF₃*Et₂O; MgSO₄ / CHCl₃ / 3 h / Heating

With boron trifluoride diethyl etherate; magnesium sulfate; potassium carbonate; In chloroform; acetonitrile;

DOI:10.1081/SCC-120021513

Reference yield: 61.0%

N-{4-bromo-2-[(3-bromo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-5-methoxyphenyl}acetamide (565227-62-5) → N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide (619297-32-4)

Guidance literature:

With dipyridine chromium trioxide; In pyridine; at 50 - 60 ℃; for 48h;

DOI:10.1081/SCC-120021513

upstream raw materials:

N-(4-bromo-3-methoxyphenyl)acetamide

[3-bromo-1-(phenylsulfonyl)indol-2-yl]methanol

3-bromo-2-(bromomethyl)-1-(phenylsulfonyl)-1H-indole

Downstream raw materials:

N-[2-(1-benzenesulfonyl-3-bromo-1H-indole-2-carbonyl)-4-bromo-5-methoxy-phenyl]-acetamide