Technology Process of 2-Oxazolidinone,
3-[(2R,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethyl-1-oxo-4
-pentenyl]-4-(phenylmethyl)-, (4R)-
There total 2 articles about 2-Oxazolidinone,
3-[(2R,3R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,4-dimethyl-1-oxo-4
-pentenyl]-4-(phenylmethyl)-, (4R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
dichloromethane;
at -78 ℃;
for 5h;
Inert atmosphere;
DOI:10.1016/j.tet.2012.10.008
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / n-Bu2BOTf; DIPEA / CH2Cl2 / -78 °C
2: 89 percent / 2,6-lutidine / CH2Cl2 / 20 °C
With
2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
DOI:10.1016/j.tetlet.2006.01.105
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 90 percent / 9-BBN; H2O2 / tetrahydrofuran; ethanol; H2O / pH 7.0
2: 90 percent / Me2AlCl / CH2Cl2 / 20 °C
3: 100 percent / imidazole; DMAP / CH2Cl2 / 20 °C
4: DIBAL-H / tetrahydrofuran / -78 °C
5: NaH / tetrahydrofuran / -78 °C
6: DIBAL-H / CH2Cl2 / -78 °C
7: m-CPBA / CH2Cl2 / 0 °C
8: 87 percent / tetrahydrofuran / -78 - -20 °C
9: 85 percent / PPTS / CH2Cl2 / 20 °C
10: DIBAL-H / CH2Cl2 / -78 °C
11: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 °C
With
1H-imidazole; dmap; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; dihydrogen peroxide; dimethylaluminum chloride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water;
5: Horner-Waddsworth-Emmons homologation / 11: Swern oxidation;
DOI:10.1016/j.tetlet.2006.01.105
