2-Oxazolidinone, 3-[(2R,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl) methoxy]-2-methyl-1-oxohexyl]-4-(phenylmethyl)-, (4R)-

Base Information

Chemical Name:2-Oxazolidinone, 3-[(2R,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl) methoxy]-2-methyl-1-oxohexyl]-4-(phenylmethyl)-, (4R)-
CAS No.:565228-99-1
Molecular Formula:C31H45NO6Si
Molecular Weight:555.787
Hs Code.:

2-Oxazolidinone,
3-[(2R,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl)
methoxy]-2-methyl-1-oxohexyl]-4-(phenylmethyl)-, (4R)-

Synonyms:

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Chemical Property of 2-Oxazolidinone, 3-[(2R,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl) methoxy]-2-methyl-1-oxohexyl]-4-(phenylmethyl)-, (4R)-

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Technology Process of 2-Oxazolidinone, 3-[(2R,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl) methoxy]-2-methyl-1-oxohexyl]-4-(phenylmethyl)-, (4R)-

There total 4 articles about 2-Oxazolidinone, 3-[(2R,3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[(4-methoxyphenyl) methoxy]-2-methyl-1-oxohexyl]-4-(phenylmethyl)-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 565229-75-6
(4R)-4-benzyl-3-[(2R,3S)-3-hydroxy-6-(4-methoxybenzyloxy)-2-methylhexanoyl]oxazolidin-2-one

: 565228-99-1
(4R)-4-benzyl-3-[(2R,3S)-3-(tert-butyldimethylsilanyloxy)-6-(4-methoxybenzyloxy)-2-methylhexanoyl]oxazolidin-2-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm0204136

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 565228-99-1
(4R)-4-benzyl-3-[(2R,3S)-3-(tert-butyldimethylsilanyloxy)-6-(4-methoxybenzyloxy)-2-methylhexanoyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / NaH / dimethylformamide

2.1: pyridinium sulfur trioxide; N,N-diisopropylethylamine / CH₂Cl₂; dimethylsulfoxide / 1 h / 20 °C

3.1: Bu₂BOTf; N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / 0 °C

3.2: CH₂Cl₂ / 2.17 h / -78 - 0 °C

3.3: 87 percent / aq. H₂O₂; phosphate buffer / CH₂Cl₂; methanol / 1 h / 0 °C / pH 7.0

4.1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0204136

Reference yield:

: 119649-45-5
4-(p-methoxybenzyloxy)butan-1-ol

: 565228-99-1
(4R)-4-benzyl-3-[(2R,3S)-3-(tert-butyldimethylsilanyloxy)-6-(4-methoxybenzyloxy)-2-methylhexanoyl]oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium sulfur trioxide; N,N-diisopropylethylamine / CH₂Cl₂; dimethylsulfoxide / 1 h / 20 °C

2.1: Bu₂BOTf; N,N-diisopropylethylamine / CH₂Cl₂ / 0.5 h / 0 °C

2.2: CH₂Cl₂ / 2.17 h / -78 - 0 °C

2.3: 87 percent / aq. H₂O₂; phosphate buffer / CH₂Cl₂; methanol / 1 h / 0 °C / pH 7.0

3.1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

With 2,6-dimethylpyridine; di-n-butylboryl trifluoromethanesulfonate; sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm0204136