N(6)-(4-(piperazinylsulfonyl)benzyl)-6-aminobenz(cd)indol-2(1H)-one

Base Information

Chemical Name:N(6)-(4-(piperazinylsulfonyl)benzyl)-6-aminobenz(cd)indol-2(1H)-one
CAS No.:138384-42-6
Molecular Formula:C24H26 N4 O3 S
Molecular Weight:422.50008
Hs Code.:
Mol file:138384-42-6.mol

Synonyms:Piperazine,1-[[4-[[(1,2-dihydro-2-oxobenz[cd]indol-6-yl)ethylamino]methyl]phenyl]sulfonyl]-(9CI); Benz[cd]indole, piperazine deriv.

Suppliers and Price of N(6)-(4-(piperazinylsulfonyl)benzyl)-6-aminobenz(cd)indol-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of N(6)-(4-(piperazinylsulfonyl)benzyl)-6-aminobenz(cd)indol-2(1H)-one

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：102.41000
Density:1.348g/cm³
LogP:3.85160

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N(6)-(4-(piperazinylsulfonyl)benzyl)-6-aminobenz(cd)indol-2(1H)-one

There total 8 articles about N(6)-(4-(piperazinylsulfonyl)benzyl)-6-aminobenz(cd)indol-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 138384-96-0
N⁶-ethyl-N⁶-<4-<<4-(tert-butoxycarbonyl)piperazinyl>sulfonyl>benzyl>-6-aminobenzindol-2(1H)-one

: 138384-42-6
N⁶-ethyl-N⁶-<4-(piperazinylsulfonyl)benzyl>-6-aminobenzindol-2(1H)-one

Guidance literature:: With hydrogenchloride; In methanol; Ambient temperature;
DOI:10.1021/jm00082a006

Reference yield:

: 10130-89-9
p-carboxyphenylsulfonyl chloride

: 138384-42-6
N⁶-ethyl-N⁶-<4-(piperazinylsulfonyl)benzyl>-6-aminobenzindol-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 53 percent / DIEA / tetrahydrofuran / 1 h

2: 91 percent / K₂CO₃ / dimethylformamide / 0.33 h

3: 93 percent / 1 M DIBAL / tetrahydrofuran; hexane / 0.5 h

4: 96 percent / Ph₃P, CBr₄ / CH₂Cl₂ / 0.33 h

5: 47 percent / K₂CO₃ / dimethylformamide / 100 °C

6: 94 percent / HCl / methanol / Ambient temperature

With hydrogenchloride; carbon tetrabromide; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a006

Reference yield:

: 143301-38-6
6-aminobenzindol-2(1H)-one hydrochloride

: 138384-42-6
N⁶-ethyl-N⁶-<4-(piperazinylsulfonyl)benzyl>-6-aminobenzindol-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 8 h / 70 - 100 °C

2: 47 percent / K₂CO₃ / dimethylformamide / 100 °C

3: 94 percent / HCl / methanol / Ambient temperature

With hydrogenchloride; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a006