Propanedioic acid, [(3-hydroxyphenyl)methyl]-, dimethyl ester

Base Information

Chemical Name:Propanedioic acid, [(3-hydroxyphenyl)methyl]-, dimethyl ester
CAS No.:565458-30-2
Molecular Formula:C12H14O5
Molecular Weight:238.24
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanedioic acid, [(3-hydroxyphenyl)methyl]-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:: SDS file from LookChem

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Technology Process of Propanedioic acid, [(3-hydroxyphenyl)methyl]-, dimethyl ester

There total 2 articles about Propanedioic acid, [(3-hydroxyphenyl)methyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(3-hydroxybenzylidene)malonic acid dimethyl ester

: 565458-30-2
2-(3-hydroxybenzyl)malonic acid dimethyl ester

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 4h; under 900.09 Torr; Large scale;
DOI:10.1021/op700093y

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 565458-30-2
2-(3-hydroxybenzyl)malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; pyridine / toluene / 24 h / 110 °C / Reflux; Inert atmosphere; Dean-Stark; Large scale

2: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 20 °C / 900.09 Torr / Large scale

With pyridine; 5%-palladium/activated carbon; hydrogen; acetic acid; In methanol; toluene; 1: |Knoevenagel Condensation;
DOI:10.1021/op700093y