N~2~-(3,4-dichlorophenyl)-N-hydroxyglycinamide

Base Information

• Chemical Name: N~2~-(3,4-dichlorophenyl)-N-hydroxyglycinamide
• CAS No.: 14108-53-3
• Molecular Formula: C8H8 Cl2 N2 O2
• Molecular Weight: 235.07
• Mol file: 14108-53-3.mol

Synonyms:Acetohydroxamicacid, 2-(3,4-dichloroanilino)- (8CI)

Chemical Property of N~2~-(3,4-dichlorophenyl)-N-hydroxyglycinamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.539g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N~2~-(3,4-dichlorophenyl)-N-hydroxyglycinamide

There total 3 articles about N~2~-(3,4-dichlorophenyl)-N-hydroxyglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

ethyl 2-((3,4-dichlorophenyl)amino)acetate (14108-81-7) → 2-(3,4-dichlorophenyl-1-ylamino)acethydroxamic acid (14108-53-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium methylate; In methanol; at 20 ℃;

DOI:10.1016/j.ejmech.2018.06.065

Reference yield:

m,p-dichloroaniline (95-76-1) → 2-(3,4-dichlorophenyl-1-ylamino)acethydroxamic acid (14108-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / Reflux

2: sodium methylate; hydroxylamine hydrochloride / methanol / 20 °C

With hydroxylamine hydrochloride; sodium methylate; potassium carbonate; In methanol;

DOI:10.1016/j.ejmech.2018.06.065

Reference yield:

→ 2-(3,4-dichlorophenyl-1-ylamino)acethydroxamic acid (14108-53-3)

Guidance literature:

N-(3,4-Dichlor-phenyl)-glycin-ethylester, Hydroxylaminhydrochlorid, Ggw. v. 1 Mol Na-Methylat;

upstream raw materials:

ethyl 2-((3,4-dichlorophenyl)amino)acetate

m,p-dichloroaniline

Refernces

• 1、 Liu, Qi,Shi, Wei-Kang,Ren, Shen-Zhen,Ni, Wei-Wei,Li, Wei-Yi,Chen, Hui-Min,Liu, Pei,Yuan, Jing,He, Xiao-Su,Liu, Jia-Jia,Cao, Peng,Yang, Pu-Zhen,Xiao, Zhu-Ping,Zhu, Hai-Liang. "Arylamino containing hydroxamic acids as potent urease inhibitors for the treatment of Helicobacter pylori infection". . p. 126 - 136. Retrieved 2018/07/13.