Technology Process of 2,7-Diazaspiro[4.5]decan-1-one,
10-[5-(3-hydroxypropyl)-3-furanyl]-2-(phenylmethyl)-7-(phenylsulfonyl)-3-[
2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (3S,5S,10R)-
There total 11 articles about 2,7-Diazaspiro[4.5]decan-1-one,
10-[5-(3-hydroxypropyl)-3-furanyl]-2-(phenylmethyl)-7-(phenylsulfonyl)-3-[
2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (3S,5S,10R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium borohydride;
In
tetrahydrofuran; methanol;
at 3 - 20 ℃;
for 19h;
DOI:10.1021/ja034464j
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium t-butoxide / tetrahydrofuran / 1.5 h / 0 - 20 °C
1.2: 96 percent / tetrahydrofuran / 1.5 h / 4 - 20 °C
2.1: 92 percent / NiCl2; NaBH4 / ethanol / 1 h / 0 °C
3.1: 82 percent / potasium acetate; PdCl2(dppf) / dimethylsulfoxide / 5 h / 82 °C
4.1: 95 percent / K3PO4; PdCl2(dppf) / dimethylformamide / 3 h / 80 °C
5.1: 92 percent / Pd/C / methanol / 1.5 h / 20 °C
6.1: 72 percent / PPTS; EtOH / methanol / 3 h / 50 °C
7.1: 96 percent / CSA / CH2Cl2 / 1.5 h / 20 °C
8.1: 94 percent / LiBH4 / methanol; tetrahydrofuran / 19 h / 3 - 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; potassium phosphate; lithium borohydride; ethanol; camphor-10-sulfonic acid; potassium acetate; pyridinium p-toluenesulfonate; nickel dichloride; sodium t-butanolate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
4.1: Suzuki-Miyaura coupling;
DOI:10.1021/ja034464j
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 82 percent / potasium acetate; PdCl2(dppf) / dimethylsulfoxide / 5 h / 82 °C
2: 95 percent / K3PO4; PdCl2(dppf) / dimethylformamide / 3 h / 80 °C
3: 92 percent / Pd/C / methanol / 1.5 h / 20 °C
4: 72 percent / PPTS; EtOH / methanol / 3 h / 50 °C
5: 96 percent / CSA / CH2Cl2 / 1.5 h / 20 °C
6: 94 percent / LiBH4 / methanol; tetrahydrofuran / 19 h / 3 - 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; lithium borohydride; ethanol; camphor-10-sulfonic acid; potassium acetate; pyridinium p-toluenesulfonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
2: Suzuki-Miyaura coupling;
DOI:10.1021/ja034464j
![ethyl 3-(4-[(3S,5S,10R)-2-benzyl-1-oxo-7-(phenylsulfonyl)-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-2,7-diazaspiro[4.5]dec-10-yl]-2-furyl)propanoate](/Databaselist/images/loading.webp)
