Thr-ser-lys-tyr-arg

Base Information

• Chemical Name: Thr-ser-lys-tyr-arg
• CAS No.: 83759-54-0
• Molecular Formula: C₂₈H₄₇N₉O₉
• Molecular Weight: 653.736
• UNII: 5ETK5E501L
• DSSTox Substance ID: DTXSID401003796
• Nikkaji Number: J759.313I
• Wikidata: Q27261937
• Mol file: 83759-54-0.mol

Synonyms:d-sero-2-NKT;neo-kyotorphin;neokyotorphin;neokyotorphine alpha137-141;Thr-Ser-Lys-Tyr-Arg;threonyl-seryl-lysyl-tyrosyl-arginine;TSKYR peptide

Chemical Property of Thr-ser-lys-tyr-arg

Chemical Property:

• PKA: 3.30±0.10(Predicted)
• PSA: 342.29000
• Density: 1.48g/cm³
• LogP: 2.00390
• XLogP3: -5.9
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 21
• Exact Mass: 653.34967411
• Heavy Atom Count: 46
• Complexity: 1020

Purity/Quality:

97% ^*data from raw suppliers

NEO-KYOTORPHIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCCN=C(N)N)C(=O)O)N)O
• Isomeric SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N)O

Technology Process of Thr-ser-lys-tyr-arg

There total 19 articles about Thr-ser-lys-tyr-arg which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Z(OMe)-Thr-D-Ser-L-Lys(Z)-Tyr-L-Arg(Tos)-OH (86579-32-0,97186-08-8,97186-09-9,97186-10-2,97458-87-2,97549-63-8) → 2>-NK (83759-54-0,97185-85-8,97185-87-0,97185-89-2,97185-91-6,97233-95-9)

Guidance literature:

With trifluorormethanesulfonic acid; methyl-phenyl-thioether; ortho-cresol; trifluoroacetic acid; at 0 ℃; for 1.5h;

DOI:10.1248/cpb.33.377

Reference yield: 84.0%

Z(OMe)-Thr-D-Ser-L-Lys(Z)-Tyr-D-Arg(Tos)-OH (86579-32-0,97186-08-8,97186-09-9,97186-10-2,97458-87-2,97549-63-8) → 2, D-Arg5>-NK (83759-54-0,97185-85-8,97185-87-0,97185-89-2,97185-91-6,97233-95-9)

Guidance literature:

With trifluorormethanesulfonic acid; methyl-phenyl-thioether; ortho-cresol; trifluoroacetic acid; at 0 ℃; for 1.5h;

DOI:10.1248/cpb.33.377

Reference yield: 64.0%

Z(OMe)-Thr-L-Ser-D-Lys(Z)-Tyr-D-Arg(Tos)-OH (86579-32-0,97186-08-8,97186-09-9,97186-10-2,97458-87-2,97549-63-8) → 3, D-Arg5>-NK (83759-54-0,97185-85-8,97185-87-0,97185-89-2,97185-91-6,97233-95-9)

Guidance literature:

With trifluorormethanesulfonic acid; methyl-phenyl-thioether; ortho-cresol; trifluoroacetic acid; at 0 ℃; for 1.5h;

DOI:10.1248/cpb.33.377

upstream raw materials:

Z(OMe)-Thr-Ser-Lys(Z)-Tyr-D-Arg(Tos)-OH

[(S)-5-[(S)-1-Azidocarbonyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-5-(4-methoxy-benzyloxycarbonylamino)-pentyl]-carbamic acid benzyl ester

Z(OMe)-Lys(Z)-Tyr-D-Arg(Tos)-OH

H-D-Arg(Tos)-OH