PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT

Base Information

• Chemical Name: PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT
• CAS No.: 4265-07-0
• Molecular Formula: C3H5 O6 P . K
• Molecular Weight: 206.133
• Hs Code.: 29199000
• Mol file: 4265-07-0.mol

Synonyms:2-Propenoicacid, 2-(phosphonooxy)-, monopotassium salt (9CI); Acrylic acid, 2-hydroxy-,dihydrogen phosphate, monopotassium salt (8CI); Monopotassiumphosphoenolpyruvate; Phosphoenolpyruvic acid potassium salt

Chemical Property of PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT

Chemical Property:

• Appearance/Colour: white to light yellow fine crystalline powder
• Vapor Pressure: 5.29E-10mmHg at 25°C
• Melting Point: 175 °C (dec.)(lit.)
• Boiling Point: 466.7 °C at 760 mmHg
• Flash Point: 236.1 °C
• PSA: 116.70000
• Density: g/cm³
• LogP: 0.13220
• Storage Temp.: −20°C
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Slightly), Water (Slightly)
• Water Solubility.: Soluble in water. Slightly soluble in methanol.

Purity/Quality:

98%, ^*data from raw suppliers

Phosphoenolpyruvate potassium salt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Phosphoenolpyruvic acid plays a role in both glycolysis and gluconeogenesis. During glycolysis, it is formed by the action of enolase on 2-phosphoglycerate and is metabolized to pyruvate by pyruvate kinase. One molecule of ATP is formed during its metabolism in this pathway. During gluconeogenesis, it is formed from phosphoenolpyruvate carboxykinase-catalyzed oxaloacetate decarboxylation and GTP hydrolysis. In plants, it is metabolized to form aromatic amino acids and also serves as a substrate for phosphoenolpyruvate carboxylase-catalyzed carbon fixation.
• Uses: Substrate for many kinase reactions. Phosphoenolpyruvic acid monopotassium salt is used in glycolysis and gluconeogeneis. It is used for regeneration of ATP from ADP in enzyme-catalyzed syntheses. It is metabolized by an enzyme namely pyruvate kinase to yield pyruvate. It acts as protection against cell injury induced by oxidative stress and against dysfunction in carbohydrate metabolism.

Technology Process of PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT

There total 2 articles about PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosphoenolpyruvic acid (138-08-9) → phospho(enol)pyruvic acid mono potassium salt (4265-07-0)

Guidance literature:

With potassium hydroxide; In ethanol; water;

DOI:10.1021/jo00140a036

Reference yield:

potassium 2-phospho-D-glycerate → phospho(enol)pyruvic acid mono potassium salt (4265-07-0)

Guidance literature:

With enzyme enolase from Saccharomyces cerevisiae; magnesium chloride; In aq. buffer; at 25 ℃; pH=7.5; Reagent/catalyst; Temperature; Kinetics; Enzymatic reaction;

DOI:10.1021/jacs.0c09423

Reference yield: 88.0%

3-Phenyl-1-propanol (122-97-4) + phospho(enol)pyruvic acid mono potassium salt (4265-07-0) → phosphoric acid mono-(3-phenyl-propyl) ester (86977-01-7)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

DOI:10.1055/a-1509-9275

upstream raw materials:

phosphoenolpyruvic acid

Downstream raw materials:

2-dehydro-3-deoxy-7-phosphono-D-arabino-heptanoic acid

chorismic acid

[4-2H]chorismic acid

2-oxo-propionic acid

Refernces

• 1、 Hirschbein, Bernard L.,Mazenod, Francois P.,Whitesides, George M.. "Synthesis of Phosphoenolpyruvate and Its Use in Adenosine Triphosphate Cofactor Regeneration". . p. 3765 - 3766. Retrieved 2007/10/02.