Glycine, N-[[1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-3-yl]-2-thienylmethyl]-N-[ (4-methylphenyl)sulfonyl]-, ethyl ester

Base Information

• Chemical Name: Glycine, N-[[1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-3-yl]-2-thienylmethyl]-N-[ (4-methylphenyl)sulfonyl]-, ethyl ester
• CAS No.: 568588-97-6
• Molecular Formula: C₃₀H₃₈N₂O₄S₂Si
• Molecular Weight: 582.86
• Mol file: 568588-97-6.mol

Synonyms:

Chemical Property of Glycine, N-[[1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-3-yl]-2-thienylmethyl]-N-[ (4-methylphenyl)sulfonyl]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Glycine, N-[[1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-3-yl]-2-thienylmethyl]-N-[ (4-methylphenyl)sulfonyl]-, ethyl ester

There total 3 articles about Glycine, N-[[1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-3-yl]-2-thienylmethyl]-N-[ (4-methylphenyl)sulfonyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

→ [[[1-(tert-butyldimethylsilyl)-1H-indol-3-yl](thiophen-2-yl)methyl]-(toluene-4-sulfonyl)amino]acetic acid ethyl ester (568588-97-6)

Guidance literature:

Reference yield:

4-methyl-N-(thiophen-2-ylmethylene)benzenesulfonamide (158293-42-6) → [[[1-(tert-butyldimethylsilyl)-1H-indol-3-yl](thiophen-2-yl)methyl]-(toluene-4-sulfonyl)amino]acetic acid ethyl ester (568588-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuLi / tetrahydrofuran; pentane / 0.25 h / -78 °C

1.2: tetrahydrofuran / 24 h / 20 °C

2.1: 43 percent / sodium ethoxide / tetrahydrofuran / 3.5 h / Heating

With tert.-butyl lithium; sodium ethanolate; In tetrahydrofuran; pentane;

DOI:10.1021/jo034290o

Reference yield:

3-bromo-1-(tert-butyl-dimethyl-silanyl)-1H-indole (153942-69-9) → [[[1-(tert-butyldimethylsilyl)-1H-indol-3-yl](thiophen-2-yl)methyl]-(toluene-4-sulfonyl)amino]acetic acid ethyl ester (568588-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuLi / tetrahydrofuran; pentane / 0.25 h / -78 °C

1.2: tetrahydrofuran / 24 h / 20 °C

2.1: 43 percent / sodium ethoxide / tetrahydrofuran / 3.5 h / Heating

With tert.-butyl lithium; sodium ethanolate; In tetrahydrofuran; pentane;

DOI:10.1021/jo034290o

upstream raw materials:

4-methyl-N-(thiophen-2-ylmethylene)benzenesulfonamide

3-bromo-1-(tert-butyl-dimethyl-silanyl)-1H-indole