Carbamic acid, [(1S)-1-[1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]-, [1-[(4-phenyl-2-thiazolyl)methyl]cyclobutyl]methyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-1-[1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]-, [1-[(4-phenyl-2-thiazolyl)methyl]cyclobutyl]methyl ester
CAS No.:568591-45-7
Molecular Formula:C31H39N3O4S
Molecular Weight:549.734
Hs Code.:

Carbamic acid,
[(1S)-1-[1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]-,
[1-[(4-phenyl-2-thiazolyl)methyl]cyclobutyl]methyl ester

Synonyms:

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Chemical Property of Carbamic acid, [(1S)-1-[1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]-, [1-[(4-phenyl-2-thiazolyl)methyl]cyclobutyl]methyl ester

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Technology Process of Carbamic acid, [(1S)-1-[1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]-, [1-[(4-phenyl-2-thiazolyl)methyl]cyclobutyl]methyl ester

There total 10 articles about Carbamic acid, [(1S)-1-[1-hydroxy-2-oxo-2-[[(1R)-1-phenylethyl]amino]ethyl]pentyl]-, [1-[(4-phenyl-2-thiazolyl)methyl]cyclobutyl]methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 497946-74-4
(3S)-3-amino-2-hydroxy-N-[(1R)-1-phenylethyl]heptanamide

: C₁₆H₁₆ClNO₂S

: 568591-45-7
{1-[(4-phenyl-1,3-thiazol-2-yl)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 6h;
DOI:10.1021/jm040107n

Reference yield:

: 4415-73-0
[1-(hydroxymethyl)cyclobutyl]methanol

: 568591-45-7
{1-[(4-phenyl-1,3-thiazol-2-yl)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

1.2: 86 percent / tetrahydrofuran; dimethylformamide / 2 h / 20 °C

2.1: Et₃N / CH₂Cl₂ / 2 h / 0 °C

3.1: 8.0 g / dimethylformamide / 5 h / 130 °C

4.1: 71 percent / diethyldithiophosphate / tetrahydrofuran; H₂O / 16 h / Heating

5.1: 83 percent / acetonitrile / 3 h / 20 °C

6.1: boron tribromide / CH₂Cl₂ / 16 h / 20 °C

7.1: CH₂Cl₂; toluene / 16 h / 0 °C

8.1: N,N-diisopropylethylamine / tetrahydrofuran / 6 h / 0 °C

With boron tribromide; sodium hydride; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm040107n

Reference yield:

: 3779-29-1
diethyl cyclobutane-1,1-dicarboxylate

: 568591-45-7
{1-[(4-phenyl-1,3-thiazol-2-yl)methyl]cyclobutyl}methyl (1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)pentylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 95 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 3 h / 20 °C

2.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

2.2: 86 percent / tetrahydrofuran; dimethylformamide / 2 h / 20 °C

3.1: Et₃N / CH₂Cl₂ / 2 h / 0 °C

4.1: 8.0 g / dimethylformamide / 5 h / 130 °C

5.1: 71 percent / diethyldithiophosphate / tetrahydrofuran; H₂O / 16 h / Heating

6.1: 83 percent / acetonitrile / 3 h / 20 °C

7.1: boron tribromide / CH₂Cl₂ / 16 h / 20 °C

8.1: CH₂Cl₂; toluene / 16 h / 0 °C

9.1: N,N-diisopropylethylamine / tetrahydrofuran / 6 h / 0 °C

With lithium aluminium tetrahydride; boron tribromide; sodium hydride; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm040107n